{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:47:14Z","timestamp":1762102034166,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,7]],"date-time":"2017-05-07T00:00:00Z","timestamp":1494115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective\/Background<\/jats:title>\n                    <jats:p>To investigate the characteristics of vomiting in pediatric migraineurs and the relationship of vomiting with other migraine\u2010related parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The cohort included children and adolescents with migraine attending a headache clinic of a tertiary pediatric medical center from 2010 to 2016. Patients were identified by a retrospective database search. Data were collected from medical files. The presence of vomiting was associated with background and headache\u2010related parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study group included 453 patients, 210 boys (46.4%) and 243 girls (53.6%), of mean age 11.3\u2009\u00b1\u20093.7 years. Vomiting was reported by 161 patients (35.5%). On comparison of patients with and without vomiting, vomiting was found to be significantly associated with male gender (54% vs 42.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.018), younger age at migraine onset (8.0\u2009\u00b1\u20093. years vs 9.6\u2009\u00b1\u20093.7 years,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), younger age at clinic admission (10.5\u2009\u00b1\u20093. years vs 11.6\u2009\u00b1\u20093.6 years,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002), higher rate of awakening headache (64.1% vs 38.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), lower headache frequency (10.5\u2009\u00b1\u200910.3 headaches\/month vs 15.0\u2009\u00b1\u200911.7 headaches\/month,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), higher rate of episodic vs chronic migraine (67% vs 58.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and higher rates of paternal migraine (24.1% vs 10.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), migraine in both parents (9.3% vs 3.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.007), and migraine in either parent (57.5% vs 45.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The higher rate of vomiting in the younger patients and the patients with awakening pain may be explained by a common underlying pathogenetic mechanism of vomiting and migraine involving autonomic nerve dysfunction\/immaturity. The association of vomiting with parental migraine points to a genetic component of vomiting and migraine. It should be noted that some of the findings may simply reflect referral patterns in the tertiary clinic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13109","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:48:28Z","timestamp":1494204508000},"page":"899-907","source":"Crossref","is-referenced-by-count":13,"title":["Vomiting and migraine\u2010related clinical parameters in pediatric migraine"],"prefix":"10.1111","volume":"57","author":[{"given":"Tal","family":"Eidlitz\u2010Markus","sequence":"first","affiliation":[{"name":"Pediatric Headache Clinic Day Hospitalization Department, Schneider Children's Medical Center of Israel, Petach Tikva; and Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishai","family":"Haimi\u2010Cohen","sequence":"additional","affiliation":[{"name":"Pediatric Headache Clinic Day Hospitalization Department, Schneider 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