{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:41:38Z","timestamp":1792989698864,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["u10 EY017281"],"award-info":[{"award-number":["u10 EY017281"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the phenotype, headache\u2010related disability, medical co\u2010morbidities, use of symptomatic headache medications, and headache response to study interventions in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with untreated IIH and mild vision loss enrolled in the IIHTT and randomized to acetazolamide (ACZ) and weight loss or placebo (PLB) and weight loss had prospective assessment of headache disability using the Headache Impact Test\u20106 (HIT\u20106) questionnaire. Subjects with headache at the baseline visit were assigned a headache phenotype using the International Classification for Headache Disorders version 3 beta (ICHD\u20103b). Medication overuse was determined using the participants' reported medication use for the preceding month and ICHD\u20103b thresholds for diagnosing medication overuse headache. We investigated relationships between headache disability and various other clinical characteristics at baseline and at 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Headache was present in 139 (84%) of the 165 enrollees at baseline. The most common headache phenotypes were migraine (52%), tension\u2010type headache (22%), probable migraine (16%), and probable tension\u2010type headache (4%). Fifty\u2010one (37%) participants overused symptomatic medications at baseline, most frequently simple analgesics. A similar amount of improvement in the adjusted mean (\u00b1 standard error) HIT\u20106 score occurred in the ACZ (\u20139.56\u2009\u00b1\u20091.05) and PLB groups (\u20139.11\u2009\u00b1\u20091.14) at 6 months (group difference \u22120.45, 95% CI \u22123.50 to 2.60,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.77). Headache disability did not correlate with any of the studies, variables of interest, which included: the lumbar puncture opening pressure at baseline or at 6 months, body mass index, the amount of weight lost, papilledema grade, perimetric mean deviation, or the use of hormonal contraception. Headache disability was significantly associated with patient\u2010reported quality of life in the physical, mental, and visual domains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Headache was common, of varied character, disabling, and associated with poorer quality of life in our cohort of patients with mild visual impairment. The lack of correlation between headache disability and cerebrospinal fluid (CSF) pressure at baseline and at the end of the randomized phase of the study implies that headache in IIH may be related to factors other than intracranial hypertension, and that specific headache treatment is needed in addition to therapies directed at lowering CSF pressure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13153","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T08:16:36Z","timestamp":1501229796000},"page":"1195-1205","source":"Crossref","is-referenced-by-count":171,"title":["Headache in Idiopathic Intracranial Hypertension: Findings From the Idiopathic Intracranial Hypertension Treatment Trial"],"prefix":"10.1111","volume":"57","author":[{"given":"Deborah I.","family":"Friedman","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of California Los Angeles Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-9179","authenticated-orcid":false,"given":"Peter A.","family":"Quiros","sequence":"additional","affiliation":[{"name":"Departments of Neurology &amp; Neurotherapeutics and Ophthalmology University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem S.","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology Neurology and Neurosurgery, University of Colorado Denver School of Medicine Aurora CO USA"},{"name":"Departments of Neurology and Ophthalmology SUNY UMU Syracuse NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J.","family":"Mejico","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Ophthalmology SUNY UMU Syracuse NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology University of Rochester School of Medicine and Dentistry Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McDermott","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics and Computational Biology Neurology; Center for Neurotherapeutics, University of Rochester School of Medicine and Dentistry Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wall","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Ophthalmology &amp; Visual Sciences University of Iowa Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the NORDIC IIHTT Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1990.1006331.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.2_Part_1.239"},{"key":"e_1_2_6_4_1","first-page":"155","article-title":"Idiopathic intracranial hypertension: A prospective study of 50 patients","volume":"114","author":"Wall M","year":"1991","journal-title":"Brain."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3312"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000114"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001687"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-002-0038-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1388-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/97.1.301"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.10.1551"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12512"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.4.0627"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.03.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12482"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414550109"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412457091"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12296"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.13153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:47:26Z","timestamp":1762087646000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.13153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/head.13153"],"URL":"https:\/\/doi.org\/10.1111\/head.13153","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]}}}