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Cortical spreading depression (SD) is an intense wave of neuronal and glial depolarization underlying migraine aura, and a headache trigger, which has been used as an experimental platform for drug screening in migraine. Here, we provide an overview of novel therapeutic targets that show promise to suppress SD, such as acid\u2010sensing ion channels, casein kinase I\u03b4, P2X7\u2010pannexin 1 complex, and neuromodulation, and outline the experimental models and essential quality measures for rigorous and reproducible efficacy testing.<\/jats:p>","DOI":"10.1111\/head.13154","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T06:22:40Z","timestamp":1503728560000},"page":"1340-1358","source":"Crossref","is-referenced-by-count":25,"title":["Novel Therapeutic Targets Against Spreading Depression"],"prefix":"10.1111","volume":"57","author":[{"given":"Shih\u2010Pin","family":"Chen","sequence":"first","affiliation":[{"name":"Neurovascular Research Lab Department of Radiology, Massachusetts General Hospital, Harvard Medical School Charlestown MA USA"},{"name":"Department of Neurology Neurological Institute, Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cenk","family":"Ayata","sequence":"additional","affiliation":[{"name":"Neurovascular Research Lab Department of Radiology, Massachusetts General Hospital, Harvard Medical School Charlestown MA USA"},{"name":"Stroke Service and Neuroscience Intensive Care Unit Department of Neurology, Massachusetts General Hospital, Harvard Medical School Charlestown MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01647.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-016-0574-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-136"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0511-10.2010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22329"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231897"},{"key":"e_1_2_7_9_1","first-page":"99","article-title":"Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1","volume":"119","author":"Eikermann\u2010Haerter K","year":"2009","journal-title":"J Clin Invest."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00085-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21815"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2013-0005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20778"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.12.13"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412470216"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000117004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410388433"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.10.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412444015"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215435109"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000175250.33159.a9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413515344"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.92"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600120"},{"key":"e_1_2_7_25_1","unstructured":"MarrannesR WauquierA ReidK DePrinsE.Effects of drugs on cortical spreading depression. 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