{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:43:54Z","timestamp":1788792234615,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Approximately 1.7 million Americans sustain a traumatic brain injury (TBI) each year and chronic pain is a common complication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We studied the effects of intranasally administered oxytocin as a potential treatment for chronic pain in an animal model of mild TBI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The lateral fluid percussion model of mild TBI was chosen for this purpose and after exposure to mild TBI the rats (n\u2009=\u200912) developed hind paw and facial allodynia compared to sham animals (n\u2009=\u20096). Oxytocin or a vehicle was afterwards administered intranasally and reactive pain was assessed by hind paw and facial von Frey testing. Some animals received the oxytocin receptor antagonist, atosiban, in addition to oxytocin\/vehicle treatment (n\u2009=\u200912). The effect of oxytocin on ongoing and spontaneous pain was examined through conditioned place preference testing. To determine whether the effects of intranasal oxytocin could be attributed to delivery via the peripheral blood stream, some TBI animals received an intravenous injection of the same oxytocin dose that was given intranasally. ELISA immunoassays were carried out (n\u2009=\u20096) to measure concentrations of oxytocin in the trigeminal ganglia, pons, spinal cord, and olfactory bulb after intranasal administration and evaluate the most likely route of entry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>These studies confirmed that the fluid percussion model can be used to study post\u2010TBI facial allodynia. Oxytocin attenuated both reactive and spontaneous, ongoing non\u2010reactive pain following mild TBI for at least 3\u20104 hours after intranasal administration by binding to OT or VA1\u2010receptors most likely by a peri\u2010trigeminal nerve mediated uptake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intranasal oxytocin attenuates measures of reactive and non\u2010reactive pain in a model of mild TBI and may represent a novel treatment for chronic pain in TBI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13248","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T10:48:15Z","timestamp":1513853295000},"page":"545-558","source":"Crossref","is-referenced-by-count":29,"title":["Intranasal Oxytocin Attenuates Reactive and Ongoing, Chronic Pain in a Model of Mild Traumatic Brain Injury"],"prefix":"10.1111","volume":"58","author":[{"given":"Anders C.","family":"Meidahl","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University, School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Eisenried","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University, School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Klukinov","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University, School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhui","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University, School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Z.","family":"Tzabazis","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University, School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-8539","authenticated-orcid":false,"given":"David C.","family":"Yeomans","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University, School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"Surveillance for traumatic brain injury\u2010related deaths\u2013United States, 1997\u20132007","volume":"60","author":"Coronado VG","year":"2011","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_9_3_1","unstructured":"Brain Injury Association of America Media Center. 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