{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:05:46Z","timestamp":1782846346861,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parenteral opioids are used in more than 50% of emergency department (ED) visits for migraine. Use of opioids for migraine has been associated with subsequent ED visits, perhaps because of opioid\u2010induced euphoria. In this study, we quantify the extent to which nontherapeutic effects of opioids influence migraine outcomes. We hypothesized that \u201cfeeling good\u201d and medication likeability would in fact be associated with receipt of opioids (rather than relief of migraine pain) and that receipt of opioids (rather than relief of migraine pain) would be associated with return visits to the ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>During an ED\u2010based clinical trial, migraine patients were randomized to receive hydromorphone 1 mg or prochlorperazine 10 mg\u2009+\u2009diphenhydramine 25 mg IV. Thirty minutes after medication administration, we asked, (1) How much did you like the medication you received? and (2) How good did the medication make you feel? Participants were asked to provide answers on a 0\u201010 scale. We also determined 0\u201010 pain scores at baseline and 1 hour and number of return visits for headache during the subsequent month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010three patients received prochlorperazine and 64 hydromorphone. Prochlorperazine pain scores improved by 6.8 (SD: 2.6), hydromorphone by 4.7 (SD: 3.3) (95%CI for difference of 2.1: 1.0, 3.2). On the 0\u201010 likeability scale, prochlorperazine patients reported a mean of 7.2 (SD: 2.8), hydromorphone 6.9 (SD: 2.9) (95% CI for difference of 0.3: \u22120.7, 1.3). On the 0\u201010 feeling good scale, prochlorperazine patients reported a mean of 7.5 (SD: 2.3), hydromorphone 6.8 (SD: 2.8) (95%CI: for difference of 0.7: \u22120.2, 1.6). In the hydromorphone group, 8\/57 (14%, 95%CI: 7, 26%) returned to the ED vs 5\/63 (8%, 95%CI: 3,18%) in the prochlorperazine group. In regression modeling, feeling good was independently associated with pain relief (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01) but not with medication received (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.67) or return visits (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.12). Similarly, medication likeability was independently associated with pain relief (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01) but not medication received (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.12) or return visits (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.16).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We did not detect an association between hydromorphone and medication likeability, feeling good, or return visits to the ED. Headache relief was associated with medication likeability and feeling good.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13292","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T01:32:50Z","timestamp":1520472770000},"page":"750-754","source":"Crossref","is-referenced-by-count":9,"title":["Opioid\u2010Induced \u201cLikeability\u201d and \u201cFeeling Good\u201d Are Not Associated With Return Visits to an ED Among Migraine Patients Administered IV Hydromorphone"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2753-5860","authenticated-orcid":false,"given":"Benjamin W.","family":"Friedman","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Albert Einstein College of Medicine Montefiore Health System Bronx NY USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Latev","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Albert Einstein College of Medicine Montefiore Health System Bronx NY USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caron","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Albert Einstein College of Medicine Montefiore Health System Bronx NY USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"White","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Albert Einstein College of Medicine Montefiore Health System Bronx NY USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414539055"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000127304.91605.BA"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.10.1662"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414557704"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004642"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.05.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01217.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1415-8"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.13292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:07:37Z","timestamp":1762085257000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.13292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,8]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/head.13292"],"URL":"https:\/\/doi.org\/10.1111\/head.13292","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,8]]}}}