{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:58:48Z","timestamp":1763535528794,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To expand the differential diagnosis of headache and ophthalmoparesis by describing a case report in which anti\u2010GQ1b was demonstrated to be the cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anti\u2010GQ1b antibody syndrome refers to a clinical spectrum of conditions that share common mechanisms and overlapping manifestations, including the Miller\u2013Fisher syndrome, pharyngeal\u2010cervical\u2010brachial weakness, and Bickerstaff brainstem encephalitis. Rare atypical cases presenting as acute ophthalmoparesis (AO) without ataxia or areflexia have been described. Headache is a rare condition in these disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 49\u2010year\u2010old woman with no history of headaches began experiencing an acute severe bilateral throbbing headache associated with nausea and photophobia. Five days later, she developed constant binocular horizontal diplopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bilateral paresis of both sixth nerves was noted. Her ocular fundi, tendon reflexes, and other findings of the physical exam were normal. In addition, both a brain MRI performed with gadolinium and a lumbar puncture yielded normal results. Serum anti\u2010GQ1b IgG was found to be positive. Her symptoms resolved completely following treatment with immunoglobulins (0.4 g\/kg\/day for 5 days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first reported case of AO related to anti\u2010GQ1b antibodies presenting with headache as its initial symptom. The presence of anti\u2010GQ1b antibodies should be determined in patients with headache and AO of unknown origin. Immunoglobulins could hasten the resolution of symptoms in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13320","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T19:53:10Z","timestamp":1527796390000},"page":"746-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Headache and Ophthalmoparesis: Case Report of an \u201cAtypical\u201d Incomplete Miller\u2013Fisher Syndrome"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-5994","authenticated-orcid":false,"given":"David","family":"Moreno\u2010Ajona","sequence":"first","affiliation":[{"name":"Department of Neurology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Irimia","sequence":"additional","affiliation":[{"name":"Department of Neurology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6732-2691","authenticated-orcid":false,"given":"Marta","family":"Fern\u00e1ndez\u2010Matarrubia","sequence":"additional","affiliation":[{"name":"Department of Neurology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1111\/ene.12769"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1136\/jnnp-2012-302824"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1016\/S0161-6420(00)00420-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1016\/j.ejpn.2016.02.002"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1002\/ana.410390517"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1212\/01.wnl.0000324266.95814.74"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1016\/S0887-8994(01)00281-8"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1007\/s004150070122"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1016\/S0887-8994(01)00362-9"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1111\/j.1526-4610.2007.00935.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1016\/j.pediatrneurol.2007.03.008"},{"key":"e_1_2_6_13_1","first-page":"1","volume-title":"The International Classification of Headache Disorders","author":"Headache Classification Committee of the International Headache Society (IHS)","year":"2018"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1093\/glycob\/cwp027"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1136\/jnnp.58.2.241"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.13320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:07:36Z","timestamp":1762085256000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.13320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/head.13320"],"URL":"https:\/\/doi.org\/10.1111\/head.13320","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"type":"print","value":"0017-8748"},{"type":"electronic","value":"1526-4610"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"2017-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}