{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:53:16Z","timestamp":1781895196588,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007698","name":"Sociedade Beneficente Israelita Brasileira Albert Einstein","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary headaches can be reduced by lifestyle changes, such as stress management and physical activity. However, access to programs focused on behavioral interventions is limited in underserved, poor communities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We performed a randomized open\u2010label clinical trial to test the therapeutic and behavioral effects of aerobic exercise, relaxation, or the combination of both, in individuals with primary headaches of a small, low\u2010income community of the Brazilian Amazon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were screened from the riverine\/rural population, and individuals with primary headache were included. We assessed clinical characteristics and physical activity levels. Interventions were delivery 3 times\/week for 6 months. The primary outcome variable was changes in days with headache, while changes in duration of attacks, pain intensity, and physical activity levels were secondary outcomes variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven hundred and ninety individuals were screened (15.3% of rural\/riverine population). Seventy\u2010four participants were randomly assigned to relaxation (n\u00a0=\u00a025), physical activity orientation program (n\u00a0=\u00a025), or both (n\u00a0=\u00a024) interventions. Intention to treat analyses showed all interventions as effective to reduce days with headaches and duration of attacks (both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Pain intensity was reduced only in relaxation and relaxation + physical activity groups (both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Physical activity levels increased only in the relaxation + physical activity group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non\u2010pharmacological interventions such as physical activity and relaxation are effective for reducing headaches, while combining such interventions promote health behavior toward higher physical activity levels in low\u2010income populations with primary headaches.<\/jats:p>\n                    <jats:p>Clinical Trial Registration number: SGPP 1544.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13457","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T14:13:12Z","timestamp":1543414392000},"page":"86-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Non\u2010Pharmacological Treatment for Primary Headaches Prevention and Lifestyle Changes in a Low\u2010Income Community of Brazil: A Randomized Clinical Trial"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0068-1905","authenticated-orcid":false,"given":"Mario","family":"Fernando Prieto Peres","sequence":"first","affiliation":[{"name":"Instituto do C\u00e9rebro, Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"},{"name":"Faculdade de Medicina, Instituto de Psiquiatria Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Prieto Peres Mercante","sequence":"additional","affiliation":[{"name":"Instituto do C\u00e9rebro, Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ar\u00e3o","family":"Belitardo de Oliveira","sequence":"additional","affiliation":[{"name":"Instituto do C\u00e9rebro, Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1249220"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01782.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01227.x"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"51\u2010","article-title":"The pharmacological treatment of migraine in Brazil","volume":"55","author":"Krymchantowski A","year":"2015","journal-title":"Arq Neuropsiquiatr"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00980.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0348-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415617413"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01846.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-016-0576-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.08.007"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411419681"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0b013e31817efac9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12738"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8031-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487141"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01507.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01899.x"},{"key":"e_1_2_8_20_1","unstructured":"IBGE.Pesquisa Nacional por Amostra de Domic\u00edlios \u2010 Pr\u00e1ticas de Esporte e Atividade F\u00edsica[Internet].2015. 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