{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:31:45Z","timestamp":1777509105753,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report a case of reversible cerebral vasoconstriction syndrome (RCVS) possibly precipitated by tocilizumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immunosuppressant drugs are a rare cause of reversible cerebral vasoconstriction, a syndrome characterized by segmental vasospasm. However, although it is considered a reversible process that resolves within 3 months, the cerebral vasoconstriction over time may lead to severe complications such as strokes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We describe a 53\u2010year\u2010old woman who presented with a reversible vasoconstriction syndrome possibly associated with tocilizumab, an inhibitor of IL\u20106 receptor used in inflammatory diseases such as rheumatoid arthritis. The patient developed a cerebellar infarction as the major complication of the vasoconstriction syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tocilizumab could be a trigger of RCVS. It is important to bear in mind the role of tocilizumab as a possible precipitating factor in order to remove it and reduce complications such as strokes. It is, to our knowledge, the first reversible vasoconstriction syndrome possibly precipitated by tocilizumab published to date.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13466","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T12:36:03Z","timestamp":1547728563000},"page":"259-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tocilizumab\u2010Associated Reversible Cerebral Vasoconstriction: A Case Report"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1228-1503","authenticated-orcid":false,"given":"Alicia","family":"Gonzalez\u2010Martinez","sequence":"first","affiliation":[{"name":"Department of Neurology &amp; Instituto de Investigaci\u00f3n Sanitaria La Princesa Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Romero\u2010Palaci\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Dotor Garc\u00eda\u2010Soto","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Instituto de Investigaci\u00f3n Sanitaria La Princesa Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Instituto de Investigaci\u00f3n Sanitaria La Princesa Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Reig Rosell\u00f3","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Instituto de Investigaci\u00f3n Sanitaria La Princesa Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2524-3637","authenticated-orcid":false,"given":"Gustavo","family":"Zapata Wainberg","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Instituto de Investigaci\u00f3n Sanitaria La Princesa Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.187856"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12797"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411410084"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.68"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12434"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12900"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.03.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-3992-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1295850"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27915"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-1-200701020-00007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12798"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.1.130"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12202"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq161"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.626184"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2000.00053.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12256"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0083-1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-552729"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0698"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.13466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:56:03Z","timestamp":1762091763000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.13466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/head.13466"],"URL":"https:\/\/doi.org\/10.1111\/head.13466","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,17]]},"assertion":[{"value":"2018-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}