{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:55:34Z","timestamp":1781106934726,"version":"3.54.1"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T00:00:00Z","timestamp":1554508800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Migraine is a complex neurological disorder characterized by severe headaches associated with a plethora of sensory hypersensitivity and neurovegetative symptoms. In about one\u2010third of the cases, a set of fully reversible focal neurological symptoms, the aura, accompanies the headache. In the last decades, advanced neuroimaging investigations allowed identification of structural, microstructural, and functional abnormalities characterizing the brain of patients with migraine with aura (MwA). However, mechanisms underlying the aura phenomena are still a matter of debate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This article reviews the most significant findings from advanced neuroimaging studies in patients with MwA both to provide a unifying physiopathological model of the aura phenomena and to clarify the potential impact of advanced neuroimaging investigation in the clinical field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive review of PubMed citations was conducted by entering the key words \u201cmagnetic resonance imaging\u201d combined with \u201cmigraine\u201d AND \u201caura.\u201d Other key words included \u201cgrey matter\u201d OR \u201cwhite matter,\u201d \u201cstructural\u201d OR \u201cfunctional.\u201d The only restriction was to English\u2010language publications. The abstracts of all articles published between\u00a01997 and 2018 meeting these criteria were reviewed, and the full texts were examined for relevance to the topic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although several advanced neuroimaging studies have been conducted to investigate the neural correlates of aura phenomena, they have failed in identifying underlying pathophysiological mechanisms in their entirety. Nevertheless, functional and structural neuroimaging findings concerning the extrastriate visual cortex are characterized by a high level of reproducibility, so much so that they could be applied, in a not so far future, as diagnostic, prognostic, or therapeutic biomarkers for MwA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13512","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T11:03:52Z","timestamp":1554548632000},"page":"637-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Recent Insights in Migraine With Aura: A Narrative Review of Advanced Neuroimaging"],"prefix":"10.1111","volume":"59","author":[{"given":"Antonio","family":"Russo","sequence":"first","affiliation":[{"name":"Headache Center, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"},{"name":"MRI 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