{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:00:28Z","timestamp":1771660828643,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T00:00:00Z","timestamp":1554595200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe a case series of 7 patients presenting cluster headache (CH) criteria and a substance use disorder, reported to a French Addictovigilance center. Then, to assess clinical, pharmacological, and neurobiological linkages between substance use and CH onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CH patients are presenting a higher prevalence of comorbidities, among which the use of psychoactive substances, licit or illicit, have been explored by a few authors. Recently, 3 cases of CH in patients seen in the hospital\u2010based addiction care center have been reported to the Toulouse addictovigilance center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Other cases have been identified in the same tertiary hospital after a collaborative investigation done with the departments of neurology and psychiatry and included in the case series. A narrative review was performed to assess the potential of psychoactive substance consumption to induce or facilitate CH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2016 to 2018, 6 males and 1 female aged between 26 and 54 years old, presenting CH criteria and a substance use disorder, were included in our case series. Among substances used, there are: (1) daily use of tobacco and alcohol in 5\/7 subjects; (2) daily or almost daily use of cocaine in 5\/7 subjects; (3) regular use of cannabis before attacks beginning in 4\/7 subjects; and (4) opioids, as a substitutive medication or abused, in 5\/7 subjects. The intranasal route administration is reported by all the subjects and precedes the beginning of attacks for 5\/7 subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We have found a CH prevalence of 0.9% in our studied population, while it is estimated at 0.1% in the general population. The coexistence of cluster headache and addiction behaviors reflects possible common neurobiological pathways, which would include the\u00a0hypothalamus. Research could be conducted on the potential of hypothalamic therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13516","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T01:15:51Z","timestamp":1554686151000},"page":"576-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cluster Headache in Subjects With Substance Use Disorder: A Case Series and a Review of the Literature"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8616-5313","authenticated-orcid":false,"given":"Camille","family":"Pont\u00e9","sequence":"first","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique, Centre d\u2019Evaluation et Information sur la Pharmacod\u00e9pendance\u2010Addictovigilance, Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Giron","sequence":"additional","affiliation":[{"name":"Service de Psychiatrie et Psychologie Universit\u00e9 de Toulouse III, Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Crequy","sequence":"additional","affiliation":[{"name":"Service Universitaire de Psychiatrie et Psychologie M\u00e9dicale, Centre de Soins d\u2019Accompagnement et de Pr\u00e9vention en Addictologie, Hopital La Grave Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryse","family":"Lapeyre\u2010Mestre","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique, Centre d\u2019Evaluation et Information sur la Pharmacod\u00e9pendance\u2010Addictovigilance, INSERM UMR 1027, CIC INSERM 1436, Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Fabre","sequence":"additional","affiliation":[{"name":"Departement de Neurologie Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Salles","sequence":"additional","affiliation":[{"name":"Service de Psychiatrie et Psychologie INSERM UMR 1043, Universit\u00e9 de Toulouse III, Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2016.07.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-017-0369-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-010-0217-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12213"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01592.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2014.03.016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00432.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.1.219"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01330.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1994.hed3403143.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0785-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-014-0413-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412458188"},{"key":"e_1_2_9_17_1","first-page":"215","article-title":"Case\u2010control study on the epidemiology of cluster headache. 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