{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:45:16Z","timestamp":1791207916491,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prevalence of migraine is high during the reproductive age. Although migraine often improves during pregnancy, the risk of adverse pregnancy, birth, neonatal, and neurological outcomes in mother and offspring remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the associations between maternal migraine and risks of adverse pregnancy outcomes in the mother, and birth, neonatal and postnatal outcomes in the offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used Danish population registries to assemble a cohort of pregnancies among women with migraine and an age\u2010 and conception year\u2010matched comparison cohort of pregnancies among women without migraine. The study period was 2005\u20102012. We computed adjusted prevalence ratios (aPRs) for pregnancy and birth outcomes and adjusted risk ratios (aRRs) for neonatal and postnatal outcomes, adjusting for age, preconception medical history, and preconception reproductive history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 22,841 pregnancies among women with migraine and 228,324 matched pregnancies among women without migraine. Migraine was associated with an increased risk of pregnancy\u2010associated hypertension disorders (aPR: 1.50 [95% confidence interval (CI): 1.39\u20101.61]) and miscarriage (aPR: 1.10 [95% CI: 1.05\u20101.15]). Migraine was associated with an increased prevalence of low birth weight (aPR: 1.14 [95% CI: 1.06\u20101.23]), preterm birth (aPR: 1.21 [95% CI: 1.13\u20101.30]) and cesarean delivery (aPR: 1.20 [95% CI: 1.15\u20101.25]), but not of small for gestational age offspring (aPR: 0.94 [95% CI: 0.88\u20100.99]) and birth defects (aPR: 1.01 [95% CI: 0.93\u20101.09]). Offspring prenatally exposed to maternal migraine had elevated risks of several outcomes in the neonatal and postnatal period, including intensive care unit admission (aRR: 1.22 [95% CI: 1.03\u20101.45]), hospitalization (aRR: 1.12 [95% CI: 1.06\u20101.18]), dispensed prescriptions (aRR: 1.34 [95% CI: 1.24\u20101.45]), respiratory distress syndrome (aRR: 1.20 [95% CI: 1.02\u20101.42]), and febrile seizures (aRR: 1.27 [95% CI: 1.03\u20101.57), but not of death (aRR: 0.67 [95% CI: 0.43\u20101.04]) and cerebral palsy (aRR: 1.00 [95% CI: 0.51\u20101.94]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women with migraine and their offspring have greater risks of several adverse pregnancy outcomes than women without migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13536","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T01:02:24Z","timestamp":1557363744000},"page":"869-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Pregnancy, Birth, Neonatal, and Postnatal Neurological Outcomes After Pregnancy With Migraine"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8351-7133","authenticated-orcid":false,"given":"Nils","family":"Skajaa","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szimonetta K.","family":"Sz\u00e9pligeti","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xue","sequence":"additional","affiliation":[{"name":"Center for Observational Research Amgen Inc. Thousand Oaks CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Ehrenstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osa","family":"Eisele","sequence":"additional","affiliation":[{"name":"Global Patient Safety and Labeling Amgen Inc. Thousand Oaks CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Adelborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"},{"name":"Department of Clinical Biochemistry Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.29"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000252808.97649.21"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-16-S1-A24"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12540"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0853-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k80"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2507"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13023"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01935.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01704.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2010.01182.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.08.025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2000.00003.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.12.030"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.54.628.98"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417724152"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_9_21_1","first-page":"988","article-title":"The Danish medical birth register","volume":"121","author":"Bliddal M","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S37587"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00045-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","unstructured":"SchmidtM SchmidtSAJ AdelborgK Sundb\u00f8llJ EhrensteinV et al. 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