{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:03:50Z","timestamp":1785153830454,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Approximately 10% of pediatric patients have recurrent headaches, with migraine being the most common headache type. If untreated, migraine may progress to status migrainosus, a debilitating condition of prolonged duration, high pain severity, and significant disability. There is high variability in the treatment of status migrainosus including medications used and treatment setting, which may occur in the emergency room, as an inpatient admission, or, less often, in an outpatient infusion center. The paucity of research on the treatment of status migrainosus is a limitation to treatment effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of the study was twofold. First, we sought to examine the demographic characteristics of children and adolescents accessing our outpatient infusion center for prolonged headache. Second, we sought to determine whether any demographic or psychosocial differences exist between patients who access infusion therapy compared to patients who do not access infusion therapy for their headaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective chart review of all patients between the ages of 6 and 19\u00a0years who were treated in our outpatient headache infusion center. A subset of these patients completed a behavioral health evaluation (treatment group) and they were compared to a control group of similar age (birthdate within 6\u00a0months) and gender to patients not seeking infusion treatment. Variables of interest included patient demographics, headache type and characteristics, and scores on the Pediatric Quality of Life Inventory (PedsQL), Functional Disability Inventory (FDI), Pediatric Pain Coping Inventory (PPCI), and the Behavior Assessment System for Children \u2013 Second Edition (BASC\u20102).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 284 patients were included in the study (n\u00a0=\u00a0227 receiving infusion treatment and n\u00a0=\u00a057 controls). Patients were primarily female (224\/286; 78.9%), Caucasian (254\/286; 90.1%), and had a mean age of 15\u00a0years. Findings suggest a promising difference in the PPCI Distraction subscale,\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      (1)\u00a0=\u00a03.7,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.054, with a mean rank score of 61.90 for the treatment group and 50.21 for the control group. Additionally, a statistically significant difference was noted on the Social Support subscale,\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      (1)\u00a0=\u00a010.6,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001, with a mean rank score of 65.92 for the treatment group and 46.26 for the control group. Results also indicated a statistically significant difference in disability scores,\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      (1)\u00a0=\u00a010.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002, with a mean rank FDI score of 66.83 for the treatment group and 47.34 for the control group. Patients in the infusion group also reported lower quality of life on the PedsQL Total score (\n                      <jats:italic>F<\/jats:italic>\n                      [1, 109]\u00a0=\u00a05.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.028; partial\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.044), and on the Physical (\n                      <jats:italic>F<\/jats:italic>\n                      [1, 109]\u00a0=\u00a07.9,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.006; partial\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.069) and School (\n                      <jats:italic>F<\/jats:italic>\n                      [1, 109]\u00a0=\u00a04.6,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.035; partial\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.041) subscales. No significant differences were found on the BASC\u20102. Parent reported data also revealed a significantly higher level of disability among patients seeking infusion treatment compared to the non\u2010infusion group\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      (1)\u00a0=\u00a011.7,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001. However, there were no significant differences on the PedsQL, PPCI, or BASC\u20102.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings support the disabling nature of migraine among children and adolescents, with higher levels of disability and lower quality of life reported in the group of patients utilizing infusion treatment. Developing concrete treatment plans and goals combined with bio\u2010behavioral therapy are necessary to reduce functional disability and increase quality of life among these patients. Awareness of this patient group's pain\u2010related coping strategies may help health\u00a0care providers tailor treatment recommendations and develop or refine cognitive\u2010behavioral headache treatment techniques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13537","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T08:09:21Z","timestamp":1555920561000},"page":"858-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Psychosocial and Demographic Characteristics of Children and Adolescents With Headache Presenting for Treatment in a Headache Infusion Center"],"prefix":"10.1111","volume":"59","author":[{"given":"Kristine","family":"Woods","sequence":"first","affiliation":[{"name":"NeuroDevelopmental Science Center Akron Children's Hospital Akron OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ostrowski\u2010Delahanty","sequence":"additional","affiliation":[{"name":"NeuroDevelopmental Science Center Akron Children's Hospital Akron OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tami","family":"Cieplinski","sequence":"additional","affiliation":[{"name":"NeuroDevelopmental Science Center Akron Children's Hospital Akron OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Winkelman","sequence":"additional","affiliation":[{"name":"NeuroDevelopmental Science Center Akron Children's Hospital Akron OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pretti","family":"Polk","sequence":"additional","affiliation":[{"name":"NeuroDevelopmental Science Center Akron Children's Hospital Akron OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Cristina","family":"Victorio","sequence":"additional","affiliation":[{"name":"NeuroDevelopmental Science Center Akron Children's Hospital Akron OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.11.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6957.765"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12701"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12253"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12694"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12746"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31816ed047"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12042"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12654"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2337"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411425960"},{"key":"e_1_2_8_14_1","first-page":"264","article-title":"Evaluation of patient satisfaction among adolescents who received infusion treatment for headache","volume":"37","author":"Winkelman J","year":"2017","journal-title":"Cephalalgia"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.e1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318192bfb1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsj063"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12251"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412468386"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01015.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.402"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2016.01.002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.1996.6.153"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199809000-00015"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12215"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.11.2034"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200108000-00006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/16.1.39"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.12.002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.02.050"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03077-1"},{"key":"e_1_2_8_32_1","volume-title":"Manual for the Behavior Assessment System for Children","author":"Reynolds CR","year":"2004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12152"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-012-0286-7"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.01.493"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610384"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282533"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.13537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:35:22Z","timestamp":1762079722000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.13537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,22]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/head.13537"],"URL":"https:\/\/doi.org\/10.1111\/head.13537","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,22]]},"assertion":[{"value":"2019-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}