{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:12Z","timestamp":1787014272531,"version":"build-2736575974"},"reference-count":101,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lamotrigine is not recommended in the prevention of migraine in general but some reports suggest that it might be effective for treating specifically migraine with aura (MA). This review aims to summarize the related data from the literature and to better understand this discrepancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All reports from the literature related to the use of lamotrigine in migraine with or without aura published prior to February 2019 found using PUBMED and the 2 keywords \u201cmigraine\u201d AND \u201clamotrigine\u201d were reviewed. Original studies, published in full, systematic reviews, and all case reports were synthetized. We also examined the risk profile, pharmacokinetics, and mode of action of lamotrigine in view of the presumed mechanism of MA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lamotrigine was tested in different populations of migraineurs, but previous studies had small sample sizes (n\u00a0&lt;\u00a035) and might not have been powered enough for detecting a potential benefit of lamotrigine in MA. Accumulating data suggest that the drug can reduce both the frequency and severity of aura symptoms in multiple conditions and is well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lamotrigine appears promising for treating attacks of MA and related clinical manifestations because of its high potential of efficacy, low\u2010risk profile, and cost. Additional studies are needed for testing lamotrigine in patients with MA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13615","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:58:16Z","timestamp":1567126696000},"page":"1187-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Lamotrigine in the Prevention of Migraine With Aura: A Narrative Review"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7966-1255","authenticated-orcid":false,"given":"Dan","family":"Buch","sequence":"first","affiliation":[{"name":"Neurology Department, DHU Neuro\u2010Vasc Hopital Lariboisi\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Chabriat","sequence":"additional","affiliation":[{"name":"Neurology Department, DHU Neuro\u2010Vasc Hopital Lariboisi\u00e8re Paris France"},{"name":"INSERM U1161 Universit\u00e9 Denis Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13101"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00748.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.436"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0910-y"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01713.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412474503"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0716-8"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0577-6"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00961.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.8.1038"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.216143"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70220-0"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.09.008"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22329"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00286.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1212\/WNL.80.7_supplement.S55.004","article-title":"Migraine headache is present in the aura phase\u2013A prospective study","volume":"80","author":"Hansen J","year":"2013","journal-title":"Neurology"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.192"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70048-5"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2216"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.08.002"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00085-6"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01120-5"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70059-4"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01094-3"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13107"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.05.010"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3563"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467208666150507093845"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-26"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2016.02.018"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01625-X"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(92)90065-2"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874205X01610010099"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64020636.x"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.008"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1995.tb05996.x"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1986.tb03525.x"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210000443"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1059-1311(95)80003-4"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.04.018"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(96)00492-4"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00085-6"},{"key":"e_1_2_13_45_1","first-page":"127","article-title":"Peripheral mechanism of action of antimigraine prophylactic drugs","volume":"29","author":"Frediani F","year":"2008","journal-title":"Neurochem Int"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20778"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.929665"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.10.014"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.03018.x"},{"key":"e_1_2_13_50_1","first-page":"1","article-title":"Propranolol blocks cardiac and neuronal voltage\u2010gated sodium channels","volume":"1","author":"Wang DW","year":"2014","journal-title":"Front Pharmacol"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01477.x"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02069.x"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199550040-00008"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01647.x"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.11.026"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-010-0297-2"},{"key":"e_1_2_13_57_1","first-page":"368","article-title":"Lamotrigine inhibits TRESK regulated by G\u2010protein coupled receptor agonists","volume":"367","author":"Yang R","year":"2018","journal-title":"J Neurosci"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485361"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01526.x"},{"key":"e_1_2_13_60_1","first-page":"1","article-title":"Modulatory effects of nitric oxide\u2010active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat","volume":"8","author":"Kim KJ","year":"2007","journal-title":"Int J Mol Sci"},{"key":"e_1_2_13_61_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1139\/jpn.0537","article-title":"Evidence for the activity of lamotrigine at 5\u2010HT1A receptors in the mouse forced swimming test","volume":"30","author":"Bourin M","year":"2005","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2017.21.2.169"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-8-47"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1999.1901064.x"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1999.1901058.x"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.063750"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04198.x"},{"issue":"1","key":"e_1_2_13_69_1","first-page":"2012","article-title":"Basilar\u2010type migraine patients responsive to lamotrigine: A 5\u2010year follow\u2010up","volume":"34","author":"Cologno D","year":"2013","journal-title":"Neurol Sci"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413520086"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1325-9"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416668655"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12392"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.01150.x"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00257"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00524"},{"key":"e_1_2_13_77_1","first-page":"103","article-title":"Treatment of migraine related vertigo with lamotrigine an observational study","volume":"2","author":"Bisdorff AR","year":"2004","journal-title":"Bull Soc Sci Med Gd Duche Luxemb"},{"issue":"10","key":"e_1_2_13_78_1","article-title":"Lamotrigine as a prophylactic treatment for migraine\u2010associated vertigo: A case series (P7.193)","volume":"82","author":"Zhang L","year":"2014","journal-title":"Neurology"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu050"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2014.06.030"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12628"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2013.06.009"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413505237"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.06.023"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300825"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1702109.x"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00599.x"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20175070"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S131021"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187118.19221.e4"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03217.x"},{"key":"e_1_2_13_92_1","first-page":"1941","article-title":"Final results from 18 years of the International Lamotrigine Pregnancy Registry","volume":"173","author":"Meissner K","year":"2013","journal-title":"Neurology"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0845-1"},{"key":"e_1_2_13_94_1","first-page":"1","article-title":"Pregnancy outcomes following in utero exposure to lamotrigine: A systematic review and meta\u2010analysis","volume":"31","author":"Pariente G","year":"2017","journal-title":"CNS Drugs"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70323-X"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12043"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000178988.78039.40"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00286.x"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.00997.x"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.10105.x"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.368"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.10391"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.13615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.13615","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:00:16Z","timestamp":1762088416000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.13615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,29]]},"references-count":101,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/head.13615"],"URL":"https:\/\/doi.org\/10.1111\/head.13615","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,29]]},"assertion":[{"value":"2019-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}