{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:44:44Z","timestamp":1789022684700,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000106","name":"Office of Integrative Activities","doi-asserted-by":"publisher","award":["EPSCoR 1632849"],"award-info":[{"award-number":["EPSCoR 1632849"]}],"id":[{"id":"10.13039\/100000106","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["26282"],"award-info":[{"award-number":["26282"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Individuals with migraine exhibit heightened sensitivity to visual input that continues beyond their migraine episodes. However, the contribution of color to visual sensitivity, and how it relates to neural activity, has largely been unexplored in these individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previously, it has been shown that, in non\u2010migraine individuals, patterns with greater chromaticity separation evoked greater cortical activity, regardless of hue, even when colors were isoluminant. Therefore, to investigate whether individuals with migraine experienced increased visual sensitivity, we compared the behavioral and neural responses to chromatic patterns of increasing separation in migraine and non\u2010migraine individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventeen individuals with migraine (12 with aura) and 18 headache\u2010free controls viewed pairs of colored horizontal grating patterns that varied in chromaticity separation. Color pairs were either blue\u2010green, red\u2010green, or red\u2010blue. Participants rated the discomfort of the gratings and electroencephalogram was recorded simultaneously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both groups showed increased discomfort ratings and larger N1\/N2 event\u2010related potentials (ERPs) with greater chromaticity separation, which is consistent with increased cortical excitability. However, individuals with migraine rated gratings as being disproportionately uncomfortable and exhibited greater effects of chromaticity separation in ERP amplitude across occipital and parietal electrodes. Ratings of discomfort and ERPs were smaller in response to the blue\u2010green color pairs than the red\u2010green and red\u2010blue gratings, but this was to an equivalent degree across the 2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Together, these findings indicate that greater chromaticity separation increases neural excitation, and that this effect is heightened in migraine, consistent with the theory that hyper\u2010excitability of the visual system is a key signature of migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13620","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T10:54:16Z","timestamp":1566903256000},"page":"1773-1787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Cortical Hyper\u2010Excitability in Migraine in Response to Chromatic Patterns"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-4412","authenticated-orcid":false,"given":"Sarah M.","family":"Haigh","sequence":"first","affiliation":[{"name":"Department of Psychology, Institute for Neuroscience University of Nevada Reno NV USA"},{"name":"Department of Psychology, Center for the Neural Basis of Cognition Carnegie Mellon University Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Chamanzar","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pulkit","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Behrmann","sequence":"additional","affiliation":[{"name":"Department of Psychology, Center for the Neural Basis of Cognition Carnegie Mellon University Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1997.3708492.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411398401"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.4.989"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460125024"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411433301"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412444474"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411409076"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414547782"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412474503"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22361"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417736899"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1998.tb02006.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apergo.2008.08.005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01502.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06476.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05302.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSA.27.000294"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2017.04.012"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.11.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2013.07.003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1068\/p7397"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00357"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00366"},{"key":"e_1_2_7_26_1","first-page":"1","article-title":"What\u2019s new in psychtoolbox\u20103","volume":"36","author":"Kleiner M","year":"2007","journal-title":"Perception"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00213"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.034"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2005.00272.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-012-1274-8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003327"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2475"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.02.004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283466c8e"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-02-00768.1993"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01372"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12536"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00025"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0716-8"},{"key":"e_1_2_7_41_1","article-title":"Cortico\u2010cortical connections of primary sensory areas and associated symptoms in migraine","volume":"3","author":"Hodkinson DJ","year":"2017","journal-title":"eNeuro"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0693-y"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0997-9"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415584360"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0006-14.2014"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2472-13.2013"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3577-09.2009"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.07.001"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5456.1273"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.140535"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-20"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0577-6"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12296"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4496-10.2011"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417698708"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101815"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0712-z"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2000.00122.x"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415610873"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417698953"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2017.05.015"},{"key":"e_1_2_7_62_1","unstructured":"2013 ME Poplawski NM Miller Flicker in solid\u2010state lighting: Measurement techniques and proposed reporting and application criteria"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12062"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01443.x"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.13620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.13620","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/head.13620","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:45:27Z","timestamp":1762083927000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.13620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,27]]},"references-count":63,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/head.13620"],"URL":"https:\/\/doi.org\/10.1111\/head.13620","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,27]]},"assertion":[{"value":"2019-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}