{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:53:50Z","timestamp":1762102430826,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n                    Trigeminal\u2010targeted treatments (TTTs), the most specific and selective therapeutic migraine approach to date, are effective in approximately 60% of patients regardless of treatment type or mechanism\n                    <jats:bold>,<\/jats:bold>\n                    at least if used alone. Sixty percent is also the proportion of migraineurs who develop migraine\u2010like episodes following experimental intravenous administration of trigeminal neuropeptides and roughly 60% is the percentage of patients with a unilateral migraine tracing the area of cutaneous distribution of the trigeminal ophthalmic branch. Hence, mechanisms other than the trigeminovascular activation are probably involved in the 40% of migraineurs who do not respond to TTTs. A closer cooperation between clinical and basic neuroscientists is needed to explore migraine models because only a careful appraisal of migraine endophenotypes may help to unravel their underlying multifaceted pathophysiological machinery.\n                  <\/jats:p>","DOI":"10.1111\/head.13635","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T07:18:22Z","timestamp":1568186302000},"page":"1659-1661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Trigeminal\u2010Targeted Treatments in Migraine: Is 60% the Magic Number?"],"prefix":"10.1111","volume":"59","author":[{"given":"Piero","family":"Barbanti","sequence":"first","affiliation":[{"name":"Headache and Pain Unit Department of Neurological, Motor and Sensorial Sciences IRCCS San Raffaele Pisana Rome Italy"},{"name":"San Raffaele University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Egeo","sequence":"additional","affiliation":[{"name":"Headache and Pain Unit Department of Neurological, Motor and Sensorial Sciences IRCCS San Raffaele Pisana Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimos D.","family":"Mitsikostas","sequence":"additional","affiliation":[{"name":"First Neurology Department School of Medicine Aeginition Hospital National &amp; Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92692-8"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12601"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0615-6"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S113614"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12618"},{"key":"e_1_2_2_8_1","unstructured":"SAMURAI: Lasmiditan Reduces Pain in Acute Migraine;2018. 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