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To date, there are no reports of NIID patients presenting with hemiplegic migraine (HM)\u2010like headache, or of HM and NIID co\u2010occurring as comorbidity, and the connection between these 2 seemingly unrelated clinical conditions has yet to be established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We present a patient with NIID who was previously diagnosed with HM. To determine the pathogenesis of HM in this NIID patient, we systematically reviewed published NIID and HM cases and cataloged them based on their clinical manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>The clinical manifestations of NIID is highly various; however, there is no case reported to date that shows HM\u2010like symptoms or cerebral edema. All documented symptomatic HM cases show vascular dysfunction to various degrees, but none of them has been shown to be correlated with NIID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our patient is the first documented case in which HM and NIID occur simultaneously. Vascular dysfunctions that cause cerebral hypoperfusion and glucose hypometabolism, two of the dominant causes of symptomatic HM, may be associated with the accumulation of eosinophilic hyaline inclusions that cause NIID. However, the existence of inclusions may also alter neuronal behavior and indirectly cause cerebral hypoperfusion and glucose hypometabolism. Further research and observations are needed to examine the relationship between HM and NIID.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13687","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T04:00:06Z","timestamp":1573185606000},"page":"382-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Interrelated Pathogenesis? Neuronal Intranuclear Inclusion Disease Combining With Hemiplegic Migraine"],"prefix":"10.1111","volume":"60","author":[{"given":"Rongfei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology The First Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiting","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Medical Center Chinese PLA General Hospital Beijing China"},{"name":"School of Medicine Nankai University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-088X","authenticated-orcid":false,"given":"Shengyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"5","article-title":"Neuronal intranuclear inclusion disease","volume":"69","author":"Sone J","year":"2017","journal-title":"Brain Nerve"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413505237"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.050"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.111006209.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0292-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.02.2010.2764"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.035600"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2014.01.014"},{"key":"e_1_2_9_10_1","unstructured":"Variation ID 403421. 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