{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:37:26Z","timestamp":1762076246402,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The primary objective of the proposed systematic review is to determine if there is an association between internalizing disorders and symptoms (ie, subclinical symptoms) and migraine in children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We will perform a peer\u2010reviewed Peer Review of Electronic Search Strategies search of MEDLINE, Embase, PsycINFO, and CINAHL from inception to December 2019. The authors will also review all reference lists of included studies for relevant citations. Observational studies on the association of pediatric migraine with internalizing disorders and symptoms will be included in this review. Case\u2010control, cohort, and cross\u2010sectional studies that include participants aged 18\u00a0years and under will be eligible for inclusion. The primary outcome for this systematic review will be migraine and the exposures of interest will include internalizing disorders (eg, major depressive disorder, dysthymia, generalized anxiety disorder, and post\u2010traumatic stress disorder) and internalizing symptoms (depression symptoms, anxiety symptoms, obsessive compulsive symptoms, and post\u2010traumatic stress symptoms). Two investigators will independently carry out an initial screen of abstracts, followed by a second screen of full\u2010text manuscripts. Data extraction will be completed by 2 independent investigators. Study quality will be assessed using the Newcastle\u2010Ottawa criteria for case\u2010control and cohort studies and using a modified version of the Newcastle\u2010Ottawa criteria for cross\u2010sectional studies. A narrative synthesis of the data will be provided and, if possible, data will be quantitatively summarized using appropriate meta\u2010analytic methods. Throughout the manuscript, the Preferred Reporting Items for Systematic Review and Meta\u2010Analysis reporting standards will be followed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The goal of this systematic review will be to provide a narrative, and if possible, quantitative summary on the association between pediatric migraine and internalizing disorders and symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The methods applied in this systematic review protocol can be used to inform the design of future systematic reviews of observational studies in headache medicine. The results of this systematic review will be used to inform the clinical community on the association between pediatric migraine and internalizing disorders and symptoms and may also be used to inform the design of future research studies in this area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13778","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T07:25:43Z","timestamp":1582615543000},"page":"761-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Internalizing Symptoms in Pediatric Migraine: A Systematic Review Protocol"],"prefix":"10.1111","volume":"60","author":[{"given":"Katherine","family":"Falla","sequence":"first","affiliation":[{"name":"Cumming School of Medicine University of Calgary Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Ronksley","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary Calgary Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Noel","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Calgary Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-811X","authenticated-orcid":false,"given":"Serena L.","family":"Orr","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary Calgary Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary Calgary 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