{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T08:21:47Z","timestamp":1774167707864,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Series of patients with SARS\u2010CoV\u20102 infection report headache in 6%\u201015% of cases, although some data suggest that the actual frequency is higher, and that headache is not associated with fever. No study published to date has analyzed the characteristics of headache in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the characteristics of COVID\u201019 related headaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a survey of Spaniard healthcare professionals who have been infected by SARS\u2010CoV\u20102 and presented headache during the course of the disease. The survey addressed respondents\u2019 medical history and headache characteristics, and we analyzed the association between both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed the responses of a sample of 112 healthcare professionals. History of migraine was reported by 20\/112 (17.9%) of respondents, history of tension\u2010type headache by 8\/112 (7.1%), and history of cluster headache was reported by a single respondent; 82\/112(73.2%) of respondents had no history of headache. Headache presented independently of fever, around the third day after symptom onset. The previous history of migraine was associated with a higher frequency of pulsating headache (20% in patients with previous migraine vs 4.3% in those with no history of migraine,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Headache is often holocranial, hemicranial, or occipital, pressing, and worsens with physical activity or head movements. Because the characteristics of the headache and the associated symptoms are heterogeneous in our survey, we suggest that several patterns with specific pathophysiological mechanisms may underlie the headache associated with COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13902","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T03:52:10Z","timestamp":1594785130000},"page":"1697-1704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Spectrum of Headaches Associated With SARS\u2010CoV\u20102 Infection: Study of Healthcare Professionals"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-682X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Porta\u2010Etessam","sequence":"first","affiliation":[{"name":"Department of Neurology Institute of Neurosciences Hospital Cl\u00ednico San Carlos IdISSC Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi A.","family":"Mat\u00edas\u2010Guiu","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neurosciences Hospital Cl\u00ednico San Carlos IdISSC Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Gonz\u00e1lez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neurosciences Hospital Cl\u00ednico San Carlos IdISSC Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"G\u00f3mez Iglesias","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neurosciences Hospital Cl\u00ednico San Carlos IdISSC Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Santos\u2010Bueso","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Cl\u00ednico San Carlos IdISSC Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Arriola\u2010Villalobos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Cl\u00ednico San Carlos IdISSC Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-1064","authenticated-orcid":false,"given":"David","family":"Garc\u00eda\u2010Azor\u00edn","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Cl\u00ednico de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Mat\u00edas\u2010Guiu","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neurosciences Hospital Cl\u00ednico San Carlos IdISSC Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25757"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25884"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.26.20044057"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.24.20042903"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.20.20025601"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040941"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.07.20032573"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.17.20037572"},{"key":"e_1_2_8_10_1","article-title":"Contexto cl\u00ednico\u2010patol\u00f3gico de las alteraciones neurol\u00f3gicas por SARS2\u2010CoV","author":"Porta\u2010Etessam J","year":"2020","journal-title":"Neurologia"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13841"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13856"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2020.03.039"},{"key":"e_1_2_8_14_1","first-page":"209","article-title":"Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia","volume":"43","author":"Liu M","year":"2020","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.23.20041913"},{"key":"e_1_2_8_16_1","unstructured":"Available at:https:\/\/www.mscbs.gob.es\/profesionales\/saludPublica\/ccayes\/alertasActual\/nCov\u2010China\/situacionActual.htm. Accessed at: 18 April 2020."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.6.3.e34"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410382794"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/323084"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13811"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000875"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2020.03.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00122"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.22.20026500"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.062"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25915"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116832"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2008597"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201005965"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.25.009084"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00172"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25728"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00404-18"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0402-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2020.04.002"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"e_1_2_8_38_1","first-page":"137","article-title":"Citoquinas y dolor","volume":"61","author":"Barros de Oliveira CM","year":"2011","journal-title":"Rev Bras Anestesiol"},{"key":"e_1_2_8_39_1","first-page":"1","article-title":"Contribution of anosmia and dysgeusia for diagnostic of COVID\u201019 in outpatients","author":"Zayet S","year":"2020","journal-title":"Infection"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.22.20040782"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.13902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.13902","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:26:48Z","timestamp":1762072008000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.13902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/head.13902"],"URL":"https:\/\/doi.org\/10.1111\/head.13902","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,15]]},"assertion":[{"value":"2020-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}