{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:39:30Z","timestamp":1783618770875,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To summarize the current literature on non\u2010steroidal anti\u2010inflammatory drug and corticosteroid use during the coronavirus disease 2019 (COVID\u201019) pandemic, recognizing that these are commonly used treatments in the field of headache medicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The use of non\u2010steroidal anti\u2010inflammatory drugs and corticosteroids in patients during the COVID\u201019 pandemic has been a controversial topic within the medical community and international and national health organizations. Lay press and social media outlets have circulated opinions on this topic despite the fact that the evidence for or against the use of these medications is sparse. In the field of headache medicine, these medications are used commonly and both patients and clinicians may have questions or hesitations pertaining to their use during the COVID\u201019 pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A detailed search of the scientific and popular literature was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There is limited literature pertaining to the safety of non\u2010steroidal anti\u2010inflammatory drugs and corticosteroids during the COVID\u201019 pandemic. To date, there are no clear scientific data that preclude the use of non\u2010steroidal anti\u2010inflammatory drugs in the general population who may acquire COVID\u201019 or in those acutely infected with the virus. Several health organizations have concluded that treatment with corticosteroids during active infection should be avoided due to concerns of prolonged viral shedding in the respiratory tract and the lack of survival benefit based on the data from past coronaviruses and influenza virus; specific exceptions exist including treatment for underlying asthma or chronic obstructive pulmonary disease, septic shock, and acute respiratory distress syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Scientific information regarding the COVID\u201019 pandemic is constantly evolving, and limited or contradictory information can lead to confusion for both patients and clinicians. It is recommended that prior to prescribing non\u2010steroidal anti\u2010inflammatory drugs and steroids for the treatment of headache, clinicians have open discussions with their patients about the potential risks and benefits of using these medications during the COVID\u201019 pandemic. This manuscript summarizes the currently available evidence and understanding about these risks and benefits to help clinicians navigate such discussions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13903","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T06:17:16Z","timestamp":1594361836000},"page":"1558-1568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["COVID\u201019 and Headache Medicine: A Narrative Review of Non\u2010Steroidal Anti\u2010Inflammatory Drug (NSAID) and Corticosteroid Use"],"prefix":"10.1111","volume":"60","author":[{"given":"Karissa N.","family":"Arca","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7172","authenticated-orcid":false,"given":"Chia\u2010Chun","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-1157","authenticated-orcid":false,"given":"Amaal J.","family":"Starling","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie E.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi B.","family":"Halker Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-7086","authenticated-orcid":false,"given":"Todd J.","family":"Schwedt","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-8537","authenticated-orcid":false,"given":"Narayan R.","family":"Kissoon","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-9430","authenticated-orcid":false,"given":"Ivan","family":"Garza","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1404-9919","authenticated-orcid":false,"given":"Todd D.","family":"Rozen","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Florida Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-0994","authenticated-orcid":false,"given":"Christoper J.","family":"Boes","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-6955","authenticated-orcid":false,"given":"Mark A.","family":"Whealy","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana H.","family":"VanderPluym","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13810"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13811"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.22.20026500"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25884"},{"key":"e_1_2_9_6_1","unstructured":"Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan China | Infectious Diseases | JAMA Neurology | JAMA Network. 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