{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:50:34Z","timestamp":1790823034259,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T00:00:00Z","timestamp":1597536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the influences of depression and anxiety on headache\u2010related disability in people with episodic migraine or chronic migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depression and anxiety are common comorbidities in people with migraine, especially among those with chronic migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional analysis of data from the longitudinal, internet\u2010based Chronic Migraine Epidemiology and Outcomes Study assessed sociodemographic and headache features, and headache\u2010related disability (Migraine Disability Assessment Scale). Four groups were defined based on scores from validated screeners for depression (9\u2010item Patient Health Questionnaire) and anxiety (7\u2010item Generalized Anxiety Disorder Scale): depression alone, anxiety alone, both, or neither.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Respondents (N\u00a0=\u00a016,788) were predominantly women (74.4% [12,494\/16,788]) and white (84.0% [14,044\/16,788]); mean age was 41 years. Depression was more likely in persons with chronic migraine vs episodic migraine (56.6% [836\/1476] vs 30.0% [4589\/15,312];\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), as were anxiety (48.4% [715\/1476] vs 28.1% 4307\/15,312];\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and coexisting depression and anxiety (42.0% [620\/1476] vs 20.8% [3192\/15,312];\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). After controlling for headache frequency and other covariates, depression alone, and anxiety alone were associated with 56.0% (rate ratio [RR], 1.56; 95% confidence interval [CI], 1.46\u20101.66) and 39.0% (RR, 1.39; 95% CI, 1.30\u20101.50) increased risks of moderate\/severe migraine\u2010related disability (both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), respectively; the combination had an even greater effect on risk of moderate\/severe disability (79.0% increase; RR, 1.79; 95% CI, 1.71\u20101.87;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Depression alone and anxiety alone are associated with greater headache\u2010related disability after controlling for sociodemographic and headache features. Coexisting depression and anxiety are more strongly associated with disability than either comorbidity in isolation. Interventions targeting depression and anxiety as well as migraine itself may improve headache\u2010related disability in people with migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13914","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T11:24:29Z","timestamp":1597577069000},"page":"1683-1696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["The Effect of Psychiatric Comorbidities on Headache\u2010Related Disability in Migraine: Results From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study"],"prefix":"10.1111","volume":"60","author":[{"given":"Richard B.","family":"Lipton","sequence":"first","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine Bronx NY USA"},{"name":"Department of Neurology Montefiore Medical Center Bronx NY USA"},{"name":"Department of Epidemiology and Population Health Albert Einstein 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