{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:22:29Z","timestamp":1772508149791,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we aimed to evaluate the frequency of the main red flags in patients with headache who do have Covid\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Headache is one of the most frequent neurologic symptoms of Coronavirus disease 2019 (Covid\u201019). Diagnosis of secondary headache disorders is still based on the presence of red flags.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional study of hospitalized patients with confirmed Covid\u201019 disease. We interrogated every patient about the presence of headache and if so, a headache expert conducted a structured interview assessing the presence and type of the main red flags. We evaluated the presence of laboratory abnormalities on admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We screened 576 consecutive patients, 130\/576 (22.6%) described headache, and 104 were included in the study. Mean age of patients was 56.7 (standard deviation: 11.2) and 66\/104 (63.4%) were female. Red flags concerning prior medical history were present in 79\/104 (76.0%) cases, and those related to the headache itself were observed in 99\/104 (95.2%) patients. All patients 104\/104 (100%) described systemic symptoms and 86\/104 (82.7%) some neurologic symptoms. Laboratory results were abnormal in 98\/104 (94.2%) cases. The most frequent red flags were fever, in 93\/104 (89.4%) patients, cough, in 89\/104 (85.6% cases), and increased C\u2010reactive protein in 84\/100 (84.0%) cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with Covid\u201019 that described the headache red flags were present in most cases. There was not any universal red flag, being necessary the comprehensive evaluation of all of them.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13927","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T13:20:39Z","timestamp":1597324839000},"page":"1664-1672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Frequency and Type of Red Flags in Patients With Covid\u201019 and Headache: A Series of 104 Hospitalized Patients"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-1064","authenticated-orcid":false,"given":"David","family":"Garc\u00eda\u2010Azor\u00edn","sequence":"first","affiliation":[{"name":"Headache Unit, Department of Neurology Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL) Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Trigo","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Talavera","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-9862","authenticated-orcid":false,"given":"Enrique","family":"Mart\u00ednez\u2010P\u00edas","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Sierra","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-682X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Porta\u2010Etessam","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology Institute of Neurosciences Hospital Cl\u00ednico San Carlos, IdISSC Madrid Spain"},{"name":"Department of Medicine Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Arenillas","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"},{"name":"Neurovascular Research Laboratory Instituto de Biolog\u00eda y Gen\u00e9tica Molecular, Universidad de Valladolid \u2013 Consejo Superior de Investigaciones Cient\u00edficas Madrid Spain"},{"name":"Department of Medicine School of Medicine Universidad de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel L.","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL) Salamanca Spain"},{"name":"Department of Medicine School of Medicine Universidad de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Director\u2010General's Opening Remarks at the Media Briefing on COVID\u201019","author":"World Health Organization","year":"2020"},{"key":"e_1_2_9_3_1","volume-title":"Coronavirus Disease (COVID\u201019). 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