{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:12Z","timestamp":1787014272673,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to quantify the health and productivity burden of migraines in Australia, measured by quality\u2010adjusted life years (QALYs), productivity\u2010adjusted life years (PALYs, a novel measure of productivity), and associated health\u2010care and broader economic costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Markov state\u2010transition model was constructed to simulate follow\u2010up of Australians aged 20\u201064\u00a0years over the next 10\u00a0years. The model was first run using current prevalence estimates of migraine. It was then rerun assuming that people with migraine hypothetically did not have the condition. Differences in outcomes between the 2 model simulations represented the health and productivity burden attributable to migraine. All data inputs were obtained from published sources. Gross domestic product (GDP) per equivalent full\u2010time worker in Australia was used to reflect the cost of each PALY (AU$177,092). Future costs and outcomes were discounted by 5% annually.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Currently, 1,274,319\u00a0million (8.5%) Australians aged 20\u201064\u00a0years have migraine. Over the next 10\u00a0years, migraine was predicted to lead to a loss of 2,577,783 (95% confidence interval [CI] 2,054,980 to 3,000,784) QALYs among this cohort (2.02 per person and 2.43% of total QALYs), and AU$1.67 (95% CI $1.16 to $2.37) billion in health\u2010care costs (AU$1313 per person, 95% CI $914 to $1862). There would also be 384,740 (95% CI 299,102 to 479,803) PALYs lost (0.30 per person and 0.53% of total PALYs), resulting in AU$68.13 (95% CI $44.42 to $98.25) billion of lost GDP (AU$53,467 per person, 95% CI $34,855 to $77,102).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Migraines impose a substantial health and economic burden on Australians of working age. Funding interventions that reduce the prevalence of migraines and\/or its effects are likely to provide sound return on investment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13969","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T14:25:01Z","timestamp":1602080701000},"page":"2291-2303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Health and Productivity Burden of Migraines in Australia"],"prefix":"10.1111","volume":"60","author":[{"given":"Susan","family":"Tu","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Vic. 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