{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:40:27Z","timestamp":1762087227544,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to describe a group of patients with chronic headache disorders (CH) and medication overuse headache (MOH) treated with intravenous chlorpromazine (IVC). We hypothesized that IVC is an effective and safe addition to well\u2010known treatment strategies for CH and MOH management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Up to 4% of the general population could experience CH. Most cases occur in women, in association with MOH. To date, evidence to support different treatment strategies is lacking. Although IVC is frequently used in the emergency room (ER), documentation on its use as supportive treatment for CH and for withdrawal management of MOH is poor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort of patients hospitalized to receive treatment for CH in a specialized neurological center in Argentina was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 35 CH patients were included. Of the 35 patients, 33 (94%) patients also presented MOH. Patients reported only minor side effects to IVC administration (mainly drowsiness and symptomatic hypotension). Three months after inpatient treatment, the number of ER visits made by these patients decreased from an average of 2.8 in the 3\u00a0months prior to hospitalization to 0.7 after it (72%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.009). Headache frequency decreased in 20\/34 (59%) patients during the same time period. Pain levels had dropped from a mean of 8 points at admission (in the scale of 1\u201010) to 2 points at discharge. In the first 3\u00a0months of follow\u2010up, the average number of days per month in which patients experienced headache decreased from 28.9 to 15.4\u00a0days (53.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this particular group of inpatients, there were no significant safety issues with IVC administration and the study might suggest that the efficacy of IVC as an add\u2010on treatment for CH and MOH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13976","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T11:33:12Z","timestamp":1601119992000},"page":"2530-2536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intravenous Chlorpromazine as Potentially Useful Treatment for Chronic Headache Disorders"],"prefix":"10.1111","volume":"60","author":[{"given":"Maria A.","family":"Ruiz Yanzi","sequence":"first","affiliation":[{"name":"Department of Neurology Fleni Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"Goicochea","sequence":"additional","affiliation":[{"name":"Headache Section Department of Neurology Fleni Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Yorio","sequence":"additional","affiliation":[{"name":"Department of Neurology Fleni Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Alessandro","sequence":"additional","affiliation":[{"name":"Department of Neurology Fleni Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio 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