{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:50:12Z","timestamp":1773057012257,"version":"3.50.1"},"reference-count":99,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>The coronavirus disease 2019 (COVID\u201019) pandemic has rapidly transformed the whole world and forced us to look through comorbid diseases and risk factors from a different perspective. COVID\u201019 shows some inherent risk factors like cardiovascular comorbidities independent from age, gender, and geographic location. One of the most peculiar features of the COVID\u201019 pandemic is that severe acute respiratory syndrome coronavirus 2 respiratory infections disproportionately impact patients with hypertension, diabetes, and other cardiovascular comorbidities rather than those with allergic respiratory diseases and immune\u2010compromised conditions. Migraine is a complex neuro\u2010vasculo\u2010inflammatory disorder that is also packed frequently with certain medical conditions including vascular disorders, hypertension, allergic diseases such as asthma and systemic inflammatory disorders. Accordingly, 2 different questions arise during the pandemic: (1) Do share comorbidities of cardiovascular diseases and hypertension increase the risk of symptomatic COVID\u201019 for migraine patients? (2) Do comorbid allergic and atopic diseases, including asthma act as opposite influencers alongside with female gender? This paper focuses on the co\u2010existence of comorbidities of COVID\u201019, in comparison with migraine, based on a wide clinical dataset and available reports. Discussed mechanisms include potential strategic roles of angiotensin\u2010converting enzyme 2, angiotensin\u2010II, and nucleotide oligomerization domain\u2010like receptor family, pyrin domain containing 3 inflammasome, playing remarkable parts in the pathogenesis of COVID\u201019 and migraine. There are also some clues about the importance of endothelial and pericyte dysfunction and neuroinflammation in COVID\u201019 infection, related to complications and survival of the patients. The large epidemiological studies as well as basic research, focusing on migraine patients with COVID\u201019 will clarify these vital questions during the upcoming periods.<\/jats:p>","DOI":"10.1111\/head.13998","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T04:04:07Z","timestamp":1604030647000},"page":"2508-2521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Are Migraine Patients at Increased Risk for Symptomatic Coronavirus Disease 2019 Due to Shared Comorbidities?"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-7733","authenticated-orcid":false,"given":"Hayrunnisa","family":"Bolay","sequence":"first","affiliation":[{"name":"Department of Neurology and Algology Medical Faculty Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aynur","family":"\u00d6zge","sequence":"additional","affiliation":[{"name":"Department of Neurology and Algology Medical Faculty Mersin University Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Ulud\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Neurology and Algology Cerrahpasa Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"Baykan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Headache Center Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"154","article-title":"Coronavirus disease 2019 (COVID\u201019) from the point of view of neurologists: Observation of neurological findings and symptoms during the combat against a pandemic","volume":"57","author":"Ozdag Acarli AN","year":"2020","journal-title":"Arch Neuropsychiatry"},{"key":"e_1_2_9_3_1","volume-title":"Coronavirus Disease 2019 (COVID\u201019). 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