{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:54:57Z","timestamp":1793066097195,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare spatial pain modulation capabilities between adolescents with and without migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Conditioned pain modulation (CPM) responses at the leg are similar in adolescents with versus without migraine. However, the anatomical region of testing may affect spatial pain modulation capabilities as differences in nociceptive processing between patients with migraine and healthy controls are found in local areas that are near the site of clinical pain but not in nonlocal areas. This study aimed to examine spatial pain modulation capabilities tested by the CPM paradigm using test stimulus applied to a\n                      <jats:italic>local<\/jats:italic>\n                      body area.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nineteen adolescents with migraine (age 14.9\u00a0\u00b1\u00a02.3, mean\u00a0\u00b1\u00a0SD; 16 female) and 20 healthy adolescents (age 13.8\u00a0\u00b1\u00a02.5, mean\u00a0\u00b1\u00a0SD; 16 female) completed this case\u2013control study at Cincinnati Children\u2019s Hospital Medical Center. Pressure pain thresholds (PPT) were assessed at the trapezius before and during immersion of the foot in a cold water bath (8\u00b0C).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the migraine group (146.0\u00a0\u00b1\u00a079.1, mean\u00a0\u00b1\u00a0SD), compared to healthy controls (248.0\u00a0\u00b1\u00a0145.5, mean\u00a0\u00b1\u00a0SD), significantly lower PPT (kilopascal) values were found (estimate\u00a0=\u00a0124.28, 95% CI: 58.98, 189.59,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; effect size:\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a01.40). No differences between the groups were found for pain intensity and unpleasantness ratings of cold\u2010water immersion nor the CPM response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study found altered ascending nociceptive processing of mechanical stimuli at the neck in adolescents with migraine. However, endogenous pain modulatory mechanisms were functional and not altered. In light of other studies, impairments in inhibitory control may not be involved in migraine pathophysiology in pediatric patients regardless of stimulus location.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14017","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:09:02Z","timestamp":1606262942000},"page":"485-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Spatial aspects of pain modulation are not disrupted in adolescents with migraine"],"prefix":"10.1111","volume":"61","author":[{"given":"Hadas","family":"Nahman\u2010Averbuch","sequence":"first","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"Center for Understanding Pediatric Pain Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH 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