{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:40:32Z","timestamp":1762080032714,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010headache literature inevitably influences headache research, but the way this interdisciplinary interaction occurs has seldom been evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Utilizing network analysis techniques within the PubMed Central (PMC) database, we illustrate a novel method by which to identify and characterize the important non\u2010headache literature with significant impact within the headache world.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the National Center for Biotechnology Information E\u2010utilities application programing interface and custom backend software, all PMC articles containing the words \u201cheadache(s)\u201d and\/or \u201cmigraine(s)\u201d in the title were identified. This generated a list of \u201cseed articles\u201d to represent the body of primary headache literature. Articles referenced by the seeds were then found, generating the list of articles with one degree of separation from the seeds (first\u2010degree neighbors). This was iterated twice more to find the second\u2010 and third\u2010degree neighbors. A directed network graph was generated for each level of separation using these articles and their referential connections. The hyperlink\u2010induced topic search (HITS) and PageRank algorithms were used on these graphs to find the top 50 articles in the network (hub and authority rank via HITS, general rank via PageRank). Removing seed articles from the ranked lists left the influential non\u2010headache articles at each level of separation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We extracted 6890 seed articles. The first\u2010, second\u2010, and third\u2010degree models contained 16,451, 105,496, and 431,748 articles, respectively. As expected, most first\u2010degree neighbors were part of the seed group (headache literature). Using HITS, at the second degree, only two seed articles were found in the top 50 hubs (none in the authorities); the majority of non\u2010seed articles were basic neuroscience, involving ion channel function or cell signaling. At the third degree, there were no seeds and all articles involved imaging\/structure of brain connectivity networks. PageRank gave more varied results, with 35\/50 second\u2010degree articles being seeds, and the remainder a mixture of articles describing rating scales (3), epidemiology\/disease burden (3), basic statistical\/trial methods (3), and mixed basic science (6). At the third degree, five were seeds; non\u2010seed articles were represented heavily by genomic mapping studies, brain connectivity networks, and ion channel\/neurotransmitter studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This work demonstrates the value of network citation analysis in the identification of interdisciplinary influences on headache medicine. Articles found with this technique via HITS identified and grouped basic science applicable to headache medicine at the molecular scale (ion channels\/transmitters), and whole\u2010brain scale (connectivity networks). Both groups have direct clinical correlates, with the former implicating pharmacological targets, and the latter implicating functional neuroanatomy and pathophysiology of various headache disorders. Likely, in\u2010depth analysis of the whole network (rather than the top 50) would reveal further clusters where the relationship to headache may not be as immediately obvious. This may not only help to guide ongoing work, but also identify new targets where seemingly unrelated work may have future applications in headache management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14022","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T08:51:59Z","timestamp":1607417519000},"page":"143-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interdisciplinary influences in headache literature: A network citation analysis of PubMed Central articles"],"prefix":"10.1111","volume":"61","author":[{"given":"Pengfei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Rutgers Robert Wood Johnson Medical School New Brunswick NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology Rutgers Robert Wood Johnson Medical School New Brunswick NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_2_1","DOI":"10.1016\/j.clineuro.2017.03.022"},{"doi-asserted-by":"publisher","key":"e_1_2_11_3_1","DOI":"10.1177\/0333102416678636"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_1","DOI":"10.5530\/jyp.2016.4.2"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.1016\/j.ipm.2007.06.006"},{"doi-asserted-by":"publisher","key":"e_1_2_11_6_1","DOI":"10.1016\/j.physrep.2017.10.001"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_1","DOI":"10.1145\/345966.345982"},{"doi-asserted-by":"publisher","key":"e_1_2_11_8_1","DOI":"10.1073\/pnas.122653799"},{"volume-title":"Entrez Programming Utilities Help","year":"2010","key":"e_1_2_11_9_1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_10_1","DOI":"10.1145\/324133.324140"},{"doi-asserted-by":"publisher","key":"e_1_2_11_11_1","DOI":"10.25080\/TCWV9851"},{"issue":"5","key":"e_1_2_11_12_1","first-page":"370","article-title":"Network analysis of headache literature citations","volume":"39","author":"Zhang P","year":"2019","journal-title":"Cephalalgia"},{"doi-asserted-by":"publisher","key":"e_1_2_11_13_1","DOI":"10.1136\/jnnp.23.1.23"},{"doi-asserted-by":"publisher","key":"e_1_2_11_14_1","DOI":"10.1523\/JNEUROSCI.0002-08.2008"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.14022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:33:46Z","timestamp":1762079626000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,8]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/head.14022"],"URL":"https:\/\/doi.org\/10.1111\/head.14022","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"type":"print","value":"0017-8748"},{"type":"electronic","value":"1526-4610"}],"subject":[],"published":{"date-parts":[[2020,12,8]]},"assertion":[{"value":"2020-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}