{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:47:48Z","timestamp":1791460068453,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000282","name":"Sir Jules Thorn Charitable Trust","doi-asserted-by":"publisher","award":["Award for Biomedical Research"],"award-info":[{"award-number":["Award for Biomedical Research"]}],"id":[{"id":"10.13039\/501100000282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013790","name":"Brain Research UK","doi-asserted-by":"publisher","award":["PhD Studentship"],"award-info":[{"award-number":["PhD Studentship"]}],"id":[{"id":"10.13039\/100013790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the effectiveness of erenumab in treating headaches in idiopathic intracranial hypertension (IIH) in whom papilledema had resolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Disability in IIH is predominantly driven by debilitating headaches with no evidence for the use of preventative therapies. Headache therapy in IIH is an urgent unmet need.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, open\u2010label study in the United Kingdom was conducted. Adult females with confirmed diagnosis of IIH now in ocular remission (papilledema resolved) with chronic headaches (\u226515\u00a0days a month) and failure of \u22653 preventative medications received erenumab 4\u2010weekly (assessments were 3\u2010monthly). The primary end point was change in monthly moderate\/severe headache days (MmsHD) from baseline (30\u2010day pretreatment period) compared to 12\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010five patients, mean (SD) age 35.3 (9)\u00a0years and mean duration of headaches 10.4 (8.4)\u00a0years with 3.7 (0.9) preventative treatment failures, were enrolled. Mean baseline MmsHD was 16.1 (4.7) and total monthly headache days (MHD) was (29) 2.3. MmsHD reduced substantially at 12\u00a0months by mean (SD) [95% CI] 10.8 (4.0) [9.5, 11.9],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 and MHD reduced by 13.0 (9.5) [10.2, 15.7],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001. Crystal clear days (days without any head pain) increased by 13.1 (9.5) [9.6, 15.3],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, headache severity (scale 0\u201310) fell by 1.3 (1.7) [0.9, 1.9],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, and monthly analgesic days reduced by 4.3 (9.2) [1.6, 6.9],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002. All these measures had improved significantly by 3\u00a0months, with a consistent significant response to 12\u00a0months. Headache impact test\u20106 score and quality of life Short Form\u201036 Health Survey significantly improved at 12\u00a0months. Sensitivity analysis revealed similar results for patients with and without a prior migraine diagnosis (28\/55 (52%) patients) or those with or without medication overuse (27\/55 (48%) patients).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides evidence for the effectiveness of erenumab to treat headaches in IIH patients with resolution of papilledema. It provides mechanistic insights suggesting that calcitonin gene\u2010related peptide is likely a modulator driving headache and a useful therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14026","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T01:19:49Z","timestamp":1607995189000},"page":"157-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Erenumab for headaches in idiopathic intracranial hypertension: A prospective open\u2010label evaluation"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-5734","authenticated-orcid":false,"given":"Andreas","family":"Yiangou","sequence":"first","affiliation":[{"name":"Metabolic Neurology Institute of Metabolism and Systems Research College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Centre for Endocrinology Diabetes and Metabolism Birmingham Health Partners Birmingham UK"},{"name":"Department of Neurology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-9352","authenticated-orcid":false,"given":"James L.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Metabolic Neurology Institute of Metabolism and Systems Research College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Centre for Endocrinology Diabetes and Metabolism Birmingham Health Partners Birmingham UK"},{"name":"Department of Neurology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Vijay","sequence":"additional","affiliation":[{"name":"Metabolic Neurology Institute of Metabolism and Systems Research College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Centre for Endocrinology Diabetes and Metabolism Birmingham Health Partners Birmingham UK"},{"name":"Department of Neurology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5622-8301","authenticated-orcid":false,"given":"Zerin","family":"Alimajstorovic","sequence":"additional","affiliation":[{"name":"Metabolic Neurology Institute of Metabolism and Systems Research College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Centre for Endocrinology Diabetes and Metabolism Birmingham Health Partners Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-802X","authenticated-orcid":false,"given":"Olivia","family":"Grech","sequence":"additional","affiliation":[{"name":"Metabolic Neurology Institute of Metabolism and Systems Research College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Centre for Endocrinology Diabetes and Metabolism Birmingham Health Partners Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5794-748X","authenticated-orcid":false,"given":"Gareth G.","family":"Lavery","sequence":"additional","affiliation":[{"name":"Metabolic Neurology Institute of Metabolism and Systems Research College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Centre for Endocrinology Diabetes and Metabolism Birmingham Health Partners Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-4437","authenticated-orcid":false,"given":"Susan P.","family":"Mollan","sequence":"additional","affiliation":[{"name":"Birmingham Neuro\u2010Ophthalmology Unit Ophthalmology Department University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-5132","authenticated-orcid":false,"given":"Alexandra J.","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Metabolic Neurology Institute of Metabolism and Systems Research College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Centre for Endocrinology Diabetes and Metabolism Birmingham Health Partners Birmingham UK"},{"name":"Department of Neurology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317440"},{"key":"e_1_2_11_3_1","article-title":"A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics","volume":"4","author":"O'Reilly MW","year":"2019","journal-title":"JCI Insight"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0521-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13153"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418782192"},{"key":"e_1_2_11_7_1","first-page":"341","article-title":"Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension: prospective cohort study","volume":"7","author":"Sinclair AJ","year":"2010","journal-title":"BMJ"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12512"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000651"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411423305"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0919-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1812"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0238-5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026573"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00232-3"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6cb72"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330109"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410368444"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00245-8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70209-1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70128-0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.227793"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30083-2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13583"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24001"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419877662"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418758283"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079901753403207"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.4730020305"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1959-2"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414550109"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2012.08.2212"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017426"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000114"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcz050"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010020\u201001182\u20107"},{"key":"e_1_2_11_41_1","article-title":"Interventions for idiopathic intracranial hypertension","volume":"8","author":"Piper RJ","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.2196\/resprot.7806"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan0972"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-03839-x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01172.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410379890"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000000346"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12152"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000315"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2012.8.2.89"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-015-2164-7"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01660.x"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.14026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:33:33Z","timestamp":1762079613000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/head.14026"],"URL":"https:\/\/doi.org\/10.1111\/head.14026","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,14]]},"assertion":[{"value":"2020-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}