{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:28:25Z","timestamp":1787592505985,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Migraine is a common disabling neurological disorder. Current acute treatments for migraine in adolescents are mostly pharmacological and may have limited effectiveness, can cause side effects, and may lead to medication overuse. There is an unmet need for effective and well\u2010tolerated treatments. Remote electrical neuromodulation (REN) is a novel acute treatment of migraine that stimulates upper arm peripheral nerves to induce conditioned pain modulation (CPM)\u2014an endogenous analgesic mechanism. The REN device (Nerivio\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , Theranica Bio\u2010Electronics Ltd., Israel) is a FDA\u2010authorized device for acute treatment of migraine in adults. This study assessed the efficacy and safety of REN in adolescents with migraine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Methods<\/jats:title>\n                    <jats:p>This was an open\u2010label, single\u2010arm, multicenter study in adolescents (ages 12\u201317\u00a0years) with migraine. Participants underwent a 4\u2010week run\u2010in phase. Eligible participants continued to an 8\u2010week treatment phase with the device. Pain severity, associated symptoms, and functional disability were recorded at treatment initiation, and 2 and 24\u00a0hours post\u2010treatment. The primary endpoints of this study were related to the safety and tolerability of REN. The secondary endpoints were related to device efficacy and included the proportion of participants who achieved pain relief at 2\u00a0hours post\u2010treatment and the proportion of participants who achieved pain freedom at 2\u00a0hours. The presented results reflect an interim analysis with subsequent stopping of the rest of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty participants were enrolled for the study; of these, 14 failed to meet the run\u2010in criteria and 1 was lost to follow\u2010up. Forty\u2010five participants performed at least one treatment, of which 39 participants completed a test treatment with REN. One device\u2010related adverse event (2%) was reported in which a temporary feeling of pain in the arm was felt. Pain relief and pain\u2010free at 2\u00a0hours were achieved by 71% (28\/39) and 35% (14\/39) participants, respectively. At 2\u00a0hours, 69% (23\/33) participants experienced improvement in functional ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>REN may offer a safe and effective non\u2010pharmacological alternative for acute treatment in adolescents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14042","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T13:33:47Z","timestamp":1608644027000},"page":"310-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Remote electrical neuromodulation for acute treatment of migraine in adolescents"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-7536","authenticated-orcid":false,"given":"Andrew D.","family":"Hershey","sequence":"first","affiliation":[{"name":"Division of 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