{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:56:26Z","timestamp":1781816186783,"version":"3.54.5"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Prior studies have established an association between a history of abuse and the development of migraine. This cross\u2010sectional observational study explored the relationship between self\u2010reported abuse history with migraine\u2010related sensory hypersensitivity symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 588 adult patients with migraine from the American Registry for Migraine Research completed questionnaires: Generalized Anxiety Disorder\u20107, Patient Health Questionnaire\u20102 for depression, Photosensitivity Assessment Questionnaire, Hyperacusis Questionnaire, and Allodynia Symptom Checklist. Using four binary screening questions, patients were asked to self\u2010report if they believed they had suffered emotional, physical, or sexual abuse in their lifetime. Differences in questionnaire scores between groups with and without a history of abuse were determined. Regression models adjusted for age, sex, and basic headache features analyzed the relationship between abuse history and sensory hypersensitivity symptoms. Moderation analysis explored the role of headache frequency in this relationship. Mediation analysis assessed the indirect (Mediated) effect (IE) of abuse on sensory hypersensitivity through depression or anxiety. Additional models analyzed relationships between sensory hypersensitivity symptoms and abuse subtypes or the number of abuse subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 588 participants, 222 (38%) reported a history of abuse. Patients with a history of abuse reported statistically significantly greater average headache frequency (7.6 vs. 4.7\u00a0days,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030). Patients with a history of abuse also reported higher average or median questionnaire scores: anxiety (7.6 vs. 4.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001,\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.56), depression (1.7 vs. 1.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009,\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.24), photophobia (0.54 vs. 0.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001,\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.32), hyperacusis (19.6 vs. 14.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001,\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.49), ictal allodynia (6.0 vs. 3.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001,\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.46), and interictal allodynia (1.0 vs. 0.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001,\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.30). After controlling for patient age, sex and years lived with headache, abuse maintained a significant association with every sensory hypersensitivity measure. Headache frequency significantly moderated the relationship between a history of abuse with increased ictal allodynia (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.036). Anxiety significantly mediated the relationships between abuse with photophobia (IE\u00a0=\u00a00.03, 95% CI\u00a0=\u00a00.01\u20130.04), hyperacusis (IE\u00a0=\u00a01.51, 95% CI\u00a0=\u00a00.91\u20132.24), ictal allodynia (IE\u00a0=\u00a00.02, 95% CI\u00a0=\u00a00.01\u20130.04), and interictal allodynia (IE\u00a0=\u00a00.02, 95% CI\u00a0=\u00a00.01\u20130.06). Depression significantly mediated the relationship between abuse with photophobia (IE\u00a0=\u00a00.02, 95% CI\u00a0=\u00a00.01\u20130.03) and with hyperacusis (IE\u00a0=\u00a00.45, 95% CI\u00a0=\u00a00.11\u20130.88). The association between the individual subtypes of abuse and the number of subtypes of abuse with sensory hypersensitivity symptoms varied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A history of abuse is associated with greater migraine\u2010related sensory hypersensitivity symptoms. To reduce the impact of abuse on migraine symptoms, future studies should explore mechanistic connections between abuse and migraine\u2010associated symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14100","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T07:21:10Z","timestamp":1617002470000},"page":"740-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of abuse on migraine\u2010related sensory hypersensitivity symptoms: Results from the American Registry for Migraine Research"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-9417","authenticated-orcid":false,"given":"Meesha","family":"Trivedi","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9519-5370","authenticated-orcid":false,"given":"Gina","family":"Dumkrieger","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9035-8748","authenticated-orcid":false,"given":"Catherine D.","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-6790","authenticated-orcid":false,"given":"David W.","family":"Dodick","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-7086","authenticated-orcid":false,"given":"Todd J.","family":"Schwedt","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2006.08.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.04.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5152\/npa.2016.8817"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12994"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u20108721.00045"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.93.7.1065"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540410040028"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2009.01558.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2010.01777.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2010.01639.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12614"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2010.01756.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109343(99)00235\u20101"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053\u2010199910000\u201000006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2010.01626.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001120"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.052159"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2009.01556.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13206"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2009.01557.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.1987.hed2706310.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13688"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.06.053"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13745"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13911"},{"key":"e_1_2_10_28_1","first-page":"167","article-title":"Sensibilita alla luce e psicopatologia: validazione del Questionario per la Valutazione della Fotosensibilita (Q.V.F.)","volume":"51","author":"Bossini L","year":"2006","journal-title":"Med Psicosomatica"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1708\/1272.14034"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20477"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/290425"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067570"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21211"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000093487.78664.3C"},{"key":"e_1_2_10_36_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470743386.ch7"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022\u20103514.51.6.1173"},{"key":"e_1_2_10_39_1","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression\u2010Based Approach","author":"Hayes AF","year":"2018"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010018\u20100642\u20109"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003\u2010066X.59.8.795"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.133.4.581"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2007.00973.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.03.026"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102015\u2010312233"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916\u2010016\u20100554\u2010z"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940\u2010016\u20100415\u20104"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww097"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2007.00776.x"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.138"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4458\u201007.2008"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010013\u20103195\u20105"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417702120"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4579"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE\u20101996\u20106305"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100404.1984.tb07812.x"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314651"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/09602011.2011.652496"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073816650036"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2012.02160.x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715002743"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.12.1746"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.91.5.753"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192513X03258313"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000001031"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000271383.60376.67"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/15299730802624585"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2011.01906.x"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103999(00)00139\u20102"},{"key":"e_1_2_10_70_1","volume-title":"Treating the Lifetime Health Effects of Childhood Victimization","author":"Kendall\u2010Tackett KA","year":"2003"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842\u2010199601000\u201000002"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey248"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/01612840050044258"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278\u20106133.13.2.130"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022\u2010006X.62.2.333"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.113.1.82"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2004.01.008"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.10.012"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.14100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:39:50Z","timestamp":1762072790000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,29]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/head.14100"],"URL":"https:\/\/doi.org\/10.1111\/head.14100","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,29]]},"assertion":[{"value":"2020-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}