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The so\u2010called indomethacin\u2010responsive headache disorders consist of a group of conditions with a very different presentation that have a particularly good response to indomethacin. The response is so distinct as to be used in the definition of two: hemicrania continua and paroxysmal hemicrania.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a narrative literature review. PubMed and the Cochrane databases were used for the literature search.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We review the main pharmacokinetic and pharmacodynamics properties of indomethacin useful for daily practice. The proposed mechanisms of action of indomethacin in the responsive headache disorders, including its effect on cerebral blood flow and intracranial pressure, with special attention to nitrergic mechanisms, are covered. The current evidence for its use in primary headache disorders, such as some trigeminal autonomic cephalalgias, cough, hypnic, exertional or sexual headache, and migraine will be covered, as well as its indication for secondary headaches, such as those of posttraumatic origin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increasing understanding of the mechanism(s) of action of indomethacin will enhance our understanding of the complex pathophysiology that might be shared by indomethacin\u2010sensitive headache disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14111","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T08:57:10Z","timestamp":1623229030000},"page":"700-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Indomethacin\u2010responsive headaches\u2014A narrative review"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-0176","authenticated-orcid":false,"given":"Maria Dolores","family":"Villar\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"},{"name":"Neurology University of California, Los Angeles Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-5994","authenticated-orcid":false,"given":"David","family":"Moreno\u2010Ajona","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"},{"name":"Neurology University of California, Los Angeles Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Chan","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Goadsby","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"},{"name":"Neurology University of California, Los Angeles Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"e_1_2_22_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_22_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198106040-00001"},{"key":"e_1_2_22_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio231232a0"},{"key":"e_1_2_22_5_1","volume-title":"NobelPrize.org. 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