{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:12Z","timestamp":1787014272587,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["NIH K24DA029262"],"award-info":[{"award-number":["NIH K24DA029262"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Chronic overlapping pain conditions (COPCs) represent a co\u2010aggregation of widespread pain disorders. We characterized differences in physical and psychosocial functioning in patients with chronic migraine (CM) and those with CM and COPCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with CM and COPCs have been identified as a distinct subgroup of patients with CM, and these patients may be vulnerable to greater symptom severity and burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from Collaborative Health Outcomes Information Registry (an open\u2010source learning health\u2010care system), completed at the patients' first visit at a large tertiary care pain management center and electronic medical records. In 1601 patients with CM, the number of non\u2010cephalic areas of pain endorsed on a body map was used to examine the differences in pain, physical and psychosocial function, adverse life experience, and health\u2010care utilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients endorsing more body map regions reported significantly worse symptoms and function across all domains. Scored on a\n                      <jats:italic>t<\/jats:italic>\n                      \u2010score metric (mean = 50, SD = 10), endorsement of one additional body map region corresponded with a 0.69\u2010point increase in pain interference (95% CI = 0.55, 0.82;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; Cohen's\n                      <jats:italic>f<\/jats:italic>\n                      \u00a0=\u00a00.328), 1.15\u2010point increase in fatigue (95% CI = 0.97, 1.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; Cohen's\n                      <jats:italic>f<\/jats:italic>\n                      \u00a0=\u00a00.432), and 1.21\u2010point decrease in physical function (95% CI = \u22121.39, \u22121.03;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; Cohen's\n                      <jats:italic>f<\/jats:italic>\n                      \u00a0=\u00a00.560). Patients with more widespread pain reported approximately 5% more physician visits (95% CI = 0.03, 0.07;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and patients reporting adverse life events prior to age 17 endorsed 22% more body map regions (95% CI = 0.11, 0.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with CM and other overlapping pain conditions as noted on the body map report significantly worse pain\u2010related physical function, psychosocial functioning, increased health\u2010care utilization, and greater association with adverse life experiences, compared with those with localized CM. This study provides further evidence that patients with CM and co\u2010occurring pain conditions are a distinct subgroup of CM and can be easily identified through patient\u2010reported outcome measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14129","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T04:06:07Z","timestamp":1624939567000},"page":"872-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Characterization of chronic overlapping pain conditions in patients with chronic migraine: A CHOIR study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-7030","authenticated-orcid":false,"given":"Meredith J.","family":"Barad","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Perioperative, and Pain Medicine Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Sturgeon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine University of Washington Medical Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative, and Pain Medicine Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj K.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative, and Pain Medicine Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C.","family":"Mackey","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative, and Pain Medicine Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2016.06.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12515"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00784.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2218-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.12.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12468"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02155.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.192492"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414552532"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004177"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13342"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007452"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13911"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-019-0116-y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.14.25"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206741"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01556.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.3.3.252"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.8.1453"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01557.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01558.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10400"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.06.007"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(00)00112-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.07.003"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.011"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9654-0"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000881"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-016-9808-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.12.004"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000313"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa060"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/abm\/kay017"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S128184"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.01.042"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000880"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.07.108"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.03.132"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191111411667"},{"key":"e_1_2_10_42_1","first-page":"201","article-title":"Application of the National Institutes of Health Patient\u2010reported Outcome Measurement Information System (PROMIS) to mental health research","volume":"14","author":"Riley WT","year":"2011","journal-title":"J Ment Health Policy Econ"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00349-9"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.7.4.524"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00463-8"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005548801037"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025570508954"},{"key":"e_1_2_10_48_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2014.09.002"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12393"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01766.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01356"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004089"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12081"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0825-z"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0986-z"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001001"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01369.x"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-012-0460-7"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12755"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01945.x"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01756.x"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000654"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa145"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-009-0057-2"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12172"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2009.00715.x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.08.038"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.14129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:57:37Z","timestamp":1762088257000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/head.14129"],"URL":"https:\/\/doi.org\/10.1111\/head.14129","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2020-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}