{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:57:39Z","timestamp":1792213059375,"version":"4.4.0"},"reference-count":216,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This narrative review aims to update the reader on the new classification of trigeminal neuralgia (TN), clinical signs, pathophysiologic evidence, and their implications on management. This review is based on the authors\u2019 collective experience and knowledge of the literature in addition to a literature search.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In recent years, the phenotype of TN has been intensively studied leading to discrete groups of patients. These include patients with TN with additional continuous pain, and patients with and without neurovascular compression of the trigeminal dorsal root entry zone. A number of associated clinical signs such as tearing and sensory changes need further research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The literature on TN was searched in PubMed with the aims of providing evidence for the recently published third edition of the\n                      <jats:italic>International Classification of Headache Disorders<\/jats:italic>\n                      (ICHD) and update the clinical phenotype and management of the TN subcategories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ICHD's new classification for TN is based on reliable clinical data, imaging, and neurophysiologic studies. The TN classification reflects current knowledge and has improved the possibility for clinicians to choose adequate management options. However, there is a lack of effective, safe drugs for the management of TN and sparse, robust data on neurosurgical options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Research into all aspects of TN\u2014diagnosis, pharmacotherapy, surgery, long\u2010term management prognosis, and natural history\u2014is needed. Research should adhere to the ICHD's schema for TN. Improved drugs are needed along with rigorous research into surgical options and their efficacy for different subtypes of TN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14144","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T14:38:29Z","timestamp":1625236709000},"page":"817-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The changing face of trigeminal neuralgia\u2014A narrative review"],"prefix":"10.1111","volume":"61","author":[{"given":"Stine","family":"Maarbjerg","sequence":"first","affiliation":[{"name":"Danish Headache Center Department of Neurology Rigshospitalet, Glostrup Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen, Glostrup Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Benoliel","sequence":"additional","affiliation":[{"name":"Department of 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