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Interviews queried participants on migraine impact on life and were audio\u2010recorded, transcribed, and summarized into a framework matrix. A master codebook was created until meaning saturation was reached and magnitude coding established code frequency. Themes and subthemes were identified using a constructivist grounded theory approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Despite most participants being treated with acute and\/or prophylactic medications, 90% (73\/81) reported migraine had a negative impact on overall life, with 68% (55\/81) endorsing specific domains of life impacted and 52% (42\/81) describing impact on emotional health. Six main themes of migraine impact emerged: (1) global negative impact on overall life; (2) impact on emotional health; (3) impact on cognitive function; (4) impact on specific domains of life (work\/career, family, social); (5) fear and avoidance (pain catastrophizing and anticipatory anxiety); and (6) internalized and externalized stigma. Participants reported how migraine (a) controls life, (b) makes life difficult, and (c) causes disability during attacks, with participants (d) experiencing a lack of control and\/or (e) attempting to push through despite migraine. Emotional health was affected through (a) isolation, (b) anxiety, (c) frustration\/anger, (d) guilt, (e) mood changes\/irritability, and (f) depression\/hopelessness. Cognitive function was affected through concentration and communication difficulties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Migraine has a global negative impact on overall life, cognitive and emotional health, work, family, and social life. Migraine contributes to isolation, frustration, guilt, fear, avoidance behavior, and stigma. A greater understanding of the deep burden of this chronic neurological disease is needed to effectively target and treat what is most important to those living with migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14151","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T08:17:18Z","timestamp":1622794638000},"page":"1004-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Learning the full impact of migraine through patient voices: A qualitative study"],"prefix":"10.1111","volume":"61","author":[{"given":"Paige M.","family":"Estave","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Wake Forest Baptist Health Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Summerlyn","family":"Beeghly","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest Baptist Health Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest Baptist Health Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlyn","family":"Margol","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest Baptist Health Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Shakir","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest Baptist Health Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geena","family":"George","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest Baptist Health Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anissa","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest Baptist Health Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Wake Forest Baptist Health Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-5769","authenticated-orcid":false,"given":"Rebecca","family":"Burch","sequence":"additional","affiliation":[{"name":"Department of Neurology Brigham and Women\u2019s Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niina","family":"Haas","sequence":"additional","affiliation":[{"name":"BrightOutcome, Inc. 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