{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:25:20Z","timestamp":1777346720906,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007420","name":"L\u00e6geforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007420","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Combined withdrawal and early preventive medication was the most effective treatment for medication overuse headache (MOH) within the first 6\u00a0months in a previous study, but results from a longer follow\u2010up period are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>(1) To measure the efficacy at 1\u00a0year of three different treatment approaches to MOH; (2) to compare withdrawal and early preventives (W+P), preventives with potential withdrawal therapy after 6\u00a0months (P+pW), and withdrawal with delayed potential preventives (W+pP); and (3) to identify predictors of chronic headache after 1\u00a0year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with MOH and migraine and\/or tension\u2010type headache were randomly assigned to one of the three outpatient treatments. Headache calendar and questionnaires were filled out. Primary outcome was a reduction in headache days\/month after 1\u00a0year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 120 patients, 96 completed 1\u2010year follow\u2010up, and all were included in our analyses. Overall headache days\/month were reduced from 24.6 (23.4\u201325.8) to 15.0 (13.0\u201317.0) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), and only 11\/96 patients (11%) relapsed. Reduction in monthly headache days was 10.3\u00a0days (95% CI: 6.7\u201313.9) in the W+P group, 10.8\u00a0days (95% CI: 7.6\u201314) in the P+pW group, and 7.9\u00a0days (95% CI: 5.1\u201310.7) in the W+pP group. No significant differences in treatment effect were seen between the three groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.377). After 1\u00a0year, 39\/96 (41%) had chronic headache. Predictors of chronic headache after 1\u00a0year were higher headache frequency (aOR 1.19; 1.09\u20131.31), more days with acute medication (aOR 1.11; 1.03\u20131.19), higher pain intensity (aOR 1.04; 1.01\u20131.08), and depression (aOR 4.7; 1.38\u201318.95), whereas higher self\u2010rated health (aOR 0.61; 0.36\u20130.97) and high caffeine consumption (aOR 0.40; 0.16\u20130.96) were predictors of a lower risk of chronic headache. No adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All treatment strategies proved effective in treating MOH with a low relapse rate. The W+P strategy leads to the fastest effect, confirming earlier treatment recommendations. Identification of predictors for chronic headache may help identify more complex patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14177","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:49:30Z","timestamp":1627580970000},"page":"1112-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Treatment of medication overuse headache: Effect and predictors after 1\u00a0year\u2014A randomized controlled trial"],"prefix":"10.1111","volume":"61","author":[{"given":"Louise N.","family":"Carlsen","sequence":"first","affiliation":[{"name":"Danish Headache Center Rigshospitalet\u2010Glostrup Valdemar Hansens Vej 5 Glostrup 2600 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-6487","authenticated-orcid":false,"given":"Carolien","family":"Rouw","sequence":"additional","affiliation":[{"name":"Danish Headache Center Rigshospitalet\u2010Glostrup Valdemar Hansens Vej 5 Glostrup 2600 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8465-8218","authenticated-orcid":false,"given":"Maria L.","family":"Westergaard","sequence":"additional","affiliation":[{"name":"Danish Headache Center Rigshospitalet\u2010Glostrup Valdemar Hansens Vej 5 Glostrup 2600 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Danish Headache Center Rigshospitalet\u2010Glostrup Valdemar Hansens Vej 5 Glostrup 2600 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Signe B.","family":"Munksgaard","sequence":"additional","affiliation":[{"name":"Danish Headache Center Rigshospitalet\u2010Glostrup Valdemar Hansens Vej 5 Glostrup 2600 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Danish Headache Center Rigshospitalet\u2010Glostrup Valdemar Hansens Vej 5 Glostrup 2600 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-5887","authenticated-orcid":false,"given":"Rigmor H.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Headache Center Rigshospitalet\u2010Glostrup Valdemar Hansens Vej 5 Glostrup 2600 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01709.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30146-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1212\/CON.0000000000000216","article-title":"Risk factors for and management of medication\u2010overuse headache","volume":"21","author":"Lipton RB","year":"2015","journal-title":"Continuum"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1179"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1715"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14268"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0402-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410364677"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1995.9056072.x"},{"key":"e_1_2_11_13_1","volume-title":"The WHOQOL BREF Introduction, Administration, Scoring and Generic Version of the Assessment","author":"WHO","year":"1996"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3510"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412469740"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqu024"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"e_1_2_11_18_1","volume-title":"Sealed Envelope: Randomisation and Online Databases for Clinical Trials"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413515338"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414521508"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417737779"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01711.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418786265"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416672493"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000063322.14078.90"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416683918"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00789.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412451363"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7975-1"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0348-y"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418783317"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.12.008"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.168864"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0806-2"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(24)01396-6"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00948.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.124"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.14177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:00:40Z","timestamp":1762077640000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/head.14177"],"URL":"https:\/\/doi.org\/10.1111\/head.14177","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"2020-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}