{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:22:30Z","timestamp":1772508150720,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Background<\/jats:title>\n                    <jats:p>Tension\u2010type headache and migraine without aura are the most common primary headaches occurring in people with demyelinating diseases, whereas cluster headache (CH) can be considered exceptional. The location of demyelinating lesions could be strategic in these cases, involving areas interacting with the trigeminovascular system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We report a case of a 54\u2010year\u2010old woman with right\u2010sided CH as the initial manifestation of multiple sclerosis and showing a left dorsal brainstem lesion on magnetic resonance imaging, in the region of the dorsal longitudinal fasciculus (DLF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our case seems to suggest a possible role of the DLF in the process that leads to CH attacks. Because neuroimaging clearly showed a lesion contralateral to CH pain, we hypothesize that some fibers from periaqueductal gray matter project to the contralateral side, besides the known ipsilateral connections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14180","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T08:33:54Z","timestamp":1628325234000},"page":"1136-1139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Secondary cluster headache due to a contralateral demyelinating periaqueductal gray matter lesion"],"prefix":"10.1111","volume":"61","author":[{"given":"Alessia","family":"Fiore","sequence":"first","affiliation":[{"name":"Neurosciences Unit Department of Medicine and Surgery University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Neurosciences Unit Department of Medicine and Surgery University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Curti","sequence":"additional","affiliation":[{"name":"Neurosciences Unit Department of Medicine and Surgery University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Bazzurri","sequence":"additional","affiliation":[{"name":"Neurosciences Unit Department of Medicine and Surgery University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Granella","sequence":"additional","affiliation":[{"name":"Neurosciences Unit Department of Medicine and Surgery University of Parma Parma Italy"},{"name":"Multiple Sclerosis Centre Department of General Medicine Parma University 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