{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:02:46Z","timestamp":1791525766907,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to characterize key features, and to assess the clinical development of common nondental facial pain syndromes such as persistent idiopathic facial pain (PIFP), trigeminal neuralgia (TN), and neuropathic facial pain (NEUROP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a longitudinal study in which prospective questionnaire data of patients presenting to a specialized outpatient clinic were collected from 2009 to 2019. A telephone interview was conducted with the same patients in 2020 to assess the natural disease history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0411 data sets of patients with chronic facial pain were compiled. Among these were\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0150 patients with PIFP,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0111 patients with TN, and\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a086 patients with NEUROP. Guideline therapy had not been initiated in 38.7% (58\/150; PIFP), 19.8% (22\/111; TN), and 33.7% (29\/86; NEUROP) patients. Of the patients with PIFP, 99.3% (149\/150) had primarily consulted a dentist due to their pain syndrome. The additional telephone interview was completed by 236 out of the 411 patients (57.4%). Dental interventions in healthy teeth had been performed with the intention to treat the pain in many patients (78\/94 [83.0%] PIFP; 34\/62 [54.8%] TN; 19\/43 [44.2%] NEUROP), including dental extractions. 11.3% (7\/43) of the patients with TN had never profited from any therapy. In contrast, 29.8% (28\/94) of the patients with PIFP had never profited from any therapy. Furthermore, the primary pharmaceutical therapy options suggested by national guidelines were, depending on the substance class, only considered to be effective by 13.8% (13\/94; antidepressants) and 14.9% (14\/94; anticonvulsants) of the patients with PIFP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Facial pain syndromes pose a considerable disease burden. Although treatment of TN seems to be effective in most patients, patients with PIFP and NEUROP report poor effectiveness even when following guideline therapy suggestions. In addition, unwarranted dental interventions are common in facial pain syndromes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14212","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T14:49:59Z","timestamp":1633790999000},"page":"1441-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Characteristics and natural disease history of persistent idiopathic facial pain, trigeminal neuralgia, and neuropathic facial pain"],"prefix":"10.1111","volume":"61","author":[{"given":"Christian","family":"Ziegeler","sequence":"first","affiliation":[{"name":"Department of Systems Neuroscience University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Brauns","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-1506","authenticated-orcid":false,"given":"Arne","family":"May","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000853"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417706349"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420908506"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1283"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet125"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411424619"},{"key":"e_1_2_11_8_1","article-title":"Altered trigeminal pain processing on brainstem level in persistent idiopathic facial pain","author":"Ziegeler C","year":"2020","journal-title":"Pain"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30233-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419893823"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"issue":"1","key":"e_1_2_11_12_1","first-page":"9","article-title":"The International Classification of Headache Disorders, 2nd edition, ICHD\u20102","volume":"24","author":"Classification Committee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1991.tb00018.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1034-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008124"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1026\/0012\u20101924.50.4.171"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.08.023"},{"key":"e_1_2_11_18_1","article-title":"Anhaltender idiopathischer Gesichtsschmerz","author":"Sommer C","journal-title":"Leitlinien F\u00fcr Diagn Ther Neurol"},{"key":"e_1_2_11_19_1","article-title":"Trigeminusneuralgie","author":"F\u00f6rderreuther S","journal-title":"Leitlinien F\u00fcr Diagn Ther Neurol"},{"key":"e_1_2_11_20_1","article-title":"Diagnose und nicht interventionelle Therapie neuropathischer Schmerzen, S2k\u2010Leitlinie","author":"Schlereth T","year":"2019","journal-title":"DGN \u2010 Dtsch Ges F\u00fcr Neurol"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416675618"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416687280"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277274.83301.c0"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13950"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/2515816319857070"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000049461.94630.63"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419897623"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3322"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.14212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:19:53Z","timestamp":1762089593000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/head.14212"],"URL":"https:\/\/doi.org\/10.1111\/head.14212","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2021-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}