{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:04:23Z","timestamp":1773306263097,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To validate the diagnoses and to investigate epidemiological data from an international, non\u2010clinic\u2010based, and large (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01604) survey of participants with cluster headache.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are several limitations in current epidemiological data in cluster headache including a lack of large non\u2010clinic\u2010based studies. There is also limited information on several aspects of cluster headache, such as pediatric incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The International Cluster Headache Questionnaire was an internet\u2010based survey that included questions on cluster headache demographics, criteria from the International Classification of Headache Disorders (ICHD), and medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 3251\u00a0subjects participated in the survey, and 1604 respondents met ICHD criteria for cluster headache. For validation, we interviewed a random sample of 5% (81\/1604) of participants and confirmed the diagnosis of cluster headache in 97.5% (79\/81). Pediatric onset was found in 27.5% (341\/1583) of participants, and only 15.2% (52\/341) of participants with pediatric onset were diagnosed before the age of 18. Men were more likely to have episodic cluster headache between ages 10 and 50, but the sex ratio was approximately equal for other ages. An overwhelming majority of respondents had at least one autonomic feature (99.0%, 1588\/1604) and had restlessness (96.6%, 1550\/1604), but many also had prototypical migrainous features including photophobia or phonophobia (50.1%, 804\/1604), pain aggravated by physical activity (31.4%, 503\/1604), or nausea and vomiting (27.5%, 441\/1604). Interestingly, the first\u2010line medications for acute treatment (oxygen) and preventive treatment (calcium channel blockers) were perceived as significantly less effective in chronic cluster headache (3.2\u00a0\u00b1\u00a01.1 and 2.1\u00a0\u00b1\u00a01.0 respectively on a 5\u2010point ordinal scale) compared with episodic cluster headache (3.5\u00a0\u00b1\u00a01.0 and 2.4\u00a0\u00b1\u00a01.1, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 for both comparisons).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cluster headache often occurs in the pediatric population, although they are typically not diagnosed until adulthood. The onset of cluster headache is the inverse of that in migraine; in migraine women are more likely to have migraine between ages 10 and 50 but the sex ratio is approximately equal otherwise. Prototypical migrainous features are not useful in differentiating cluster headache from migraine. Participant data from a large international study also suggest that chronic cluster headache is not only less responsive to newer treatments (like noninvasive vagus nerve stimulation and galcanezumab), but to traditional first\u2010line treatments as well.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14237","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T23:43:45Z","timestamp":1638143025000},"page":"1511-1520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cluster headache epidemiology including pediatric onset, sex, and ICHD criteria: Results from the International Cluster Headache Questionnaire"],"prefix":"10.1111","volume":"61","author":[{"given":"Larry I.","family":"Schor","sequence":"first","affiliation":[{"name":"Department of Psychology University of West Georgia  Carrollton Georgia 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