{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:22:54Z","timestamp":1776118974438,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isolated cortical vein thrombosis (ICVT), a rare type of cerebral venous thrombosis (CVT), is diagnostically challenging in some cases, and intracranial hypotension (IH) is known to cause CVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we reviewed the clinical and imaging characteristics of ICVT in patients with IH caused by spinal cerebrospinal fluid leakage, based on a literature review and investigation of cases from our hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between January 1, 2007, and November 1, 2019, 735 patients were diagnosed with IH at our hospital; three patients developed ICVT (incidence ~ 0.4%, 3\/735), and the literature review yielded an additional 23 cases. Therefore, 26 patients (mean age 35.9\u00a0\u00b1\u00a011.4 years old) were included in this study. The most common symptoms were headache (100.0%, 26\/26), focal neurological deficits (53.8%, 14\/26), and seizure (34.6%, 9\/26). The initial headache was orthostatic in 96.2% (25\/26) of patients, and 38.5% (10\/26) of patients reported a change in the headache pattern following diagnosis of ICVT. Neuroimaging findings associated with ICVT included the cord sign (61.5%, 16\/26) and parenchymal brain lesions (46.2%, 12\/26), such as intracerebral hemorrhage (30.8%, 8\/26), hemorrhagic infarcts (11.5%, 3\/26), and localized edema (11.5%, 3\/26). The percentage of patients who received anticoagulation and epidural blood patch therapy was similar (69.2% [18\/26] vs. 65.4% [17\/26]), and most patients recovered completely (92.3%, 24\/26).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IH should be considered in the differential diagnosis in patients with ICVT. Knowledge of the relevant clinical and neuroimaging features is important to facilitate early diagnosis for favorable prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14254","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T01:49:30Z","timestamp":1644371370000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intracranial hypotension as a contributor to isolated cortical vein thrombosis"],"prefix":"10.1111","volume":"62","author":[{"given":"Dan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University Hangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University 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