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Many patients show a rapid therapeutic response to indomethacin, which is limited by intolerability. Etoricoxib and celecoxib, selective inhibitors of cyclo\u2010oxygenase\u20102 (COX\u20102), spare gastroduodenal COX\u20101 activity and are less likely to cause gastrointestinal adverse effects than indomethacin. 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