{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:20:00Z","timestamp":1780449600009,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T00:00:00Z","timestamp":1649548800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess real\u2010world effectiveness, safety, and usage of erenumab in Canadian patients with episodic and chronic migraine with prior ineffective prophylactic treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In randomized controlled trials, erenumab demonstrated efficacy for migraine prevention in patients with \u22644 prior ineffective prophylactic migraine therapies. The \u201cMigraine prevention with AimoviG: Informative Canadian real\u2010world study\u201d (MAGIC) assessed real\u2010world effectiveness of erenumab in Canadian patients with migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MAGIC was a prospective open\u2010label, observational study conducted in Canadian patients with chronic migraine (CM) and episodic migraine (EM) with two to six categories of prior ineffective prophylactic therapies. Participants were administered 70 mg or 140 mg erenumab monthly based on physician\u2019s assessment. Migraine attacks were self\u2010assessed using an electronic diary and patient\u2010reported outcome questionnaires. The primary outcome was the proportion of subjects achieving \u226550% reduction in monthly migraine days (MMD) after the 3\u2010month treatment period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 95 participants who mostly experienced two (54.7%) or three (32.6%) prior categories of ineffective prophylactic therapies and who initiated erenumab, treatment was generally safe and well tolerated; 89\/95 (93.7%) participants initiated treatment with 140 mg erenumab. At week 12, 32\/95 (33.7%) participants including 17\/64 (26.6%) CM and 15\/32 (48.4%) EM achieved \u226550% reduction in MMD while 30\/86 (34.9%) participants including 19\/55 (34.5%) CM and 11\/31 (35.5%) EM achieved \u226550% reduction in MMD at week 24. Through patient\u2010reported outcome questionnaires, 62\/95 (65.3%) and 45\/86 (52.3%) participants reported improvement of their condition at weeks 12 and 24, respectively. Physicians observed improvement in the condition of 78\/95 (82.1%) and 67\/86 (77.9%) participants at weeks 12 and 24, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One\u2010third of patients with EM and CM achieved \u226550% MMD reduction after 3 months of erenumab treatment. This study provides real\u2010world evidence of erenumab effectiveness, safety, and usage for migraine prevention in adult Canadian patients with multiple prior ineffective prophylactic treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14291","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T02:42:44Z","timestamp":1649644964000},"page":"522-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A real\u2010world, observational study of erenumab for migraine prevention in Canadian patients"],"prefix":"10.1111","volume":"62","author":[{"given":"Werner J.","family":"Becker","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Spacey","sequence":"additional","affiliation":[{"name":"Division of Neurology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Leroux","sequence":"additional","affiliation":[{"name":"Brunswick Medical Center  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Giammarco","sequence":"additional","affiliation":[{"name":"Hamilton Headache Clinic  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gladstone","sequence":"additional","affiliation":[{"name":"Gladstone Headache Clinic  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Christie","sequence":"additional","affiliation":[{"name":"Ottawa Headache Centre Inc.  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