{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:39:31Z","timestamp":1767890371944,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013327","name":"H. Lundbeck A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the utility of the novel patient\u2010identified (PI) most bothersome symptom (MBS) measure from PROMISE\u20102, a phase 3 trial of eptinezumab for the preventive treatment of chronic migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Relief of bothersome migraine symptoms can influence satisfaction with treatment and therapeutic persistence. Understanding the impact of preventive treatment on a PI\u2010MBS could improve clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In PROMISE\u20102, patients with chronic migraine received eptinezumab 100, 300\u00a0mg, or placebo administered intravenously every 12\u00a0weeks for up to 2 doses (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01072). PI\u2010MBS was an exploratory outcome requiring each patient to self\u2010report their MBS in response to an open\u2010ended question. At baseline and week 12, patients rated overall improvement in PI\u2010MBS. The relationships among PI\u2010MBS at week 12 and change in monthly migraine days (MMDs) from baseline to month 3 (weeks 9\u201312), Patient Global Impression of Change at week 12, and changes from baseline to week 12 in the 6\u2010item Headache Impact Test total, EuroQol 5\u2010dimensions 5\u2010levels visual analog scale, and 36\u2010item Short\u2010Form Health Survey component scores were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment groups had similar baseline characteristics and reported a total of 23 unique PI\u2010MBS, most commonly light sensitivity (200\/1072, 18.7%), nausea\/vomiting (162\/1072, 15.1%), and pain with activity (147\/1072, 13.7%). Improvements in PI\u2010MBS at week 12 correlated with changes in MMDs (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a0\u22120.49;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) and other patient\u2010reported outcomes. Controlling for changes in MMDs, PI\u2010MBS improvement predicted other patient\u2010reported outcomes in expected directions. The magnitude of the standardized mean differences between placebo and active treatment for PI\u2010MBS were 0.31 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001 vs. placebo) and 0.54 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001 vs. placebo) for eptinezumab 100 and 300\u00a0mg, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Improvement in PI\u2010MBS at week 12 was associated with improvement in other patient\u2010reported outcome measures, and PI\u2010MBS may be an important patient\u2010centered measure of treatment benefits in patients with chronic migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14295","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T04:54:42Z","timestamp":1650862482000},"page":"690-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluating the clinical utility of the patient\u2010identified most bothersome symptom measure from PROMISE\u20102 for research in migraine prevention"],"prefix":"10.1111","volume":"62","author":[{"given":"Richard B.","family":"Lipton","sequence":"first","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Goadsby","sequence":"additional","affiliation":[{"name":"NIHR\u2010Wellcome Trust King\u2019s Clinical Research Facility King\u2019s College Hospital  London UK"},{"name":"Department of Neurology University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-6790","authenticated-orcid":false,"given":"David W.","family":"Dodick","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"McGinley","sequence":"additional","affiliation":[{"name":"Vector Psychometric Group, LLC  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie R.","family":"Houts","sequence":"additional","affiliation":[{"name":"Vector Psychometric Group, LLC  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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