{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:37:19Z","timestamp":1788907039106,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23NS116453"],"award-info":[{"award-number":["K23NS116453"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to describe treatment preferences and perceived quality of existing outcome measures among children and adolescents with migraine and their caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Across disciplines, there is increasing recognition of the value of direct input from stakeholders. Little empirical work has been done to determine what outcomes matter most to pediatric patients with migraine and their caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this qualitative study, we recruited participants from the multicenter, prospective Pediatric Migraine Registry. We used stratified purposive sampling to recruit children and adolescents of varied ages and headache frequency. Patients with migraine and their caregivers completed semistructured interviews targeting treatment preferences and perceived quality of existing outcome measures. Emergent themes and subthemes were identified using conventional content analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty dyads of children\/adolescents and their caregivers were enrolled and completed 59 interviews (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a029 children\/adolescent interviews and\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030 caregiver interviews). Three themes emerged. (1)\n                      <jats:italic>Symptom relief<\/jats:italic>\n                      :\n                      <jats:italic>Looking beyond headache resolution<\/jats:italic>\n                      : Participants described the value of outcomes in addition to pain relief, including a reduction in migraine intensity and improvement in non\u2010pain symptoms. (2)\n                      <jats:italic>Trade<\/jats:italic>\n                      \u2010\n                      <jats:italic>offs between side effects and relief<\/jats:italic>\n                      : Participants described cost\u2010benefit analyses that can occur with headache treatment and acknowledged the impact of drug side effects on daily life and medication adherence. (3)\n                      <jats:italic>Child<\/jats:italic>\n                      \u2010\n                      <jats:italic>centered treatment<\/jats:italic>\n                      : Participants described medication attributes salient to the pediatric context, including age\u2010appropriate routes of administration and adequate safety data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children, adolescents, and caregivers impacted by migraine value outcomes in addition to traditionally studied migraine endpoints. Participants valued decreased pain severity, even in the absence of pain resolution. Participants also prioritized the absence of side effects and key medication attributes, including fast onset and age\u2010appropriate routes of administration. These results highlight an opportunity to design patient\u2010centered clinical trials, develop drugs, and support product labeling that align with the outcomes valued most by children and adolescents with migraine and their caregivers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14315","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T02:25:19Z","timestamp":1651890319000},"page":"588-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Beyond pain control: Outcome and treatment preferences in pediatric migraine"],"prefix":"10.1111","volume":"62","author":[{"given":"Matthew J.","family":"Khayata","sequence":"first","affiliation":[{"name":"Department of Pediatrics Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Farley","sequence":"additional","affiliation":[{"name":"School of Social Work University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Fuqua School of Business Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Kelly","family":"Davis","sequence":"additional","affiliation":[{"name":"Fuqua School of Business Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-8759","authenticated-orcid":false,"given":"Christoph P.","family":"Hornik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Clinical Research Institute Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce B.","family":"Reeve","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine  Durham North Carolina USA"},{"name":"Department of Population Health Sciences Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Rikhi","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy A.","family":"Gelfand","sequence":"additional","affiliation":[{"name":"Department of Neurology UCSF Child &amp; Adolescent Headache Program  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-8889","authenticated-orcid":false,"given":"Christina L.","family":"Szperka","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Kessel","sequence":"additional","affiliation":[{"name":"Miles for Migraine  Lafayette Hill Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Pezzuto","sequence":"additional","affiliation":[{"name":"Nemours Neurology Headache Program Alfred I. 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