{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:51:47Z","timestamp":1792205507970,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,6]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n No studies have evaluated the glymphatic system function in patients with migraine. In this pilot study, we evaluated and compared the alterations in the glymphatic system function in patients with migraine with healthy controls using a diffusion tensor imaging (DTI) analysis along the perivascular space (DTI\u2010ALPS) method. We also investigated the differences in the glymphatic system function table between patients with migraine with and without aura using the ALPS method.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This field study used a cross\u2010sectional study design. We prospectively enrolled patients with migraine and healthy controls. All brain magnetic resonance imaging (MRI), including DTI, in participants, patients with migraine, and healthy controls were obtained using the same MRI scanner. We calculated and compared the ALPS index between patients with migraine and healthy controls, and between patients with migraine with and without aura. In addition, we investigated the association between the glymphatic system function and the clinical characteristics of migraine.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We enrolled 92 patients with migraine and 80\u00a0healthy controls. There were no significant differences in the ALPS index between patients with migraine and healthy controls (1.655\u00a0\u00b1\u00a00.335 [patients with migraine] vs. 1.713\u00a0\u00b1\u00a00.297 [controls], difference = 0.058, 95% confidence interval [CI] of difference = \u22120.037 to 0.154,\n p<\/jats:italic>\n \u00a0=\u00a00.233), and between patients with migraine with and without aura (1.690\u00a0\u00b1\u00a00.380 [with aura] vs. 1.645\u00a0\u00b1\u00a00.323 [without aura], difference = \u22120.044, 95% CI of difference = \u22120.213 to 0.124,\n p<\/jats:italic>\n \u00a0=\u00a00.601). There was no significant correlation between the ALPS index and clinical characteristics of migraine, including age (\n r<\/jats:italic>\n = \u22120.07,\n p<\/jats:italic>\n \u00a0=\u00a00.507), age at onset (\n r<\/jats:italic>\n \u00a0=\u00a00.07,\n p<\/jats:italic>\n \u00a0=\u00a00.552), disease duration (\n r<\/jats:italic>\n = \u22120.12,\n p<\/jats:italic>\n \u00a0=\u00a00.306), attack frequency (\n r<\/jats:italic>\n = \u22120.05,\n p<\/jats:italic>\n \u00a0=\u00a00.668), and headache intensity (\n r<\/jats:italic>\n \u00a0=\u00a00.00,\n p<\/jats:italic>\n \u00a0=\u00a00.976).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n There was no glymphatic system dysfunction in patients with migraine. Moreover, there were no differences in the glymphatic system function between patients with migraine with and without aura. We also demonstrated the feasibility of the ALPS method, which can be used for research on various neurological diseases. Further studies are needed to confirm our findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.14320","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T23:24:59Z","timestamp":1652311499000},"page":"718-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Normal glymphatic system function in patients with migraine: A pilot study"],"prefix":"10.1111","volume":"62","author":[{"given":"Dong Ah","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology Haeundae Paik Hospital Inje University College of Medicine Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Haeundae Paik Hospital Inje University College of Medicine Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-7741","authenticated-orcid":false,"given":"Kang Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Haeundae Paik Hospital Inje University College of Medicine Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.041007646.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32160-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03793.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490349"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8739"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3390-16.2017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23604"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2018-000197"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.12.039"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2020.0042"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006617"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67677"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-017-0617-z"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420919098"},{"issue":"7","key":"e_1_2_10_18_1","article-title":"Are 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