{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:36:44Z","timestamp":1774683404851,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A2B5B01001933"],"award-info":[{"award-number":["2022R1A2B5B01001933"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the clinical features of patients with medication\u2010overuse headache (MOH) according to the class of acute medications being overused.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>MOH is a common global health problem, severely disabling the majority of the patients affected. Although various medications can cause MOH, whether clinical features differ according to the overused medication type remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from a multicenter cross\u2010sectional study in neurology clinics in Korea from April 2020 to June 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 229 eligible patients, MOH was documented in patients who overused multiple drug classes (69\/229, 30.1%; most frequent occurrence), triptans (50\/229, 21.8%), non\u2010opioid analgesics (48\/229, 21.0%), and combination\u2010analgesics (40\/229, 17.4%). Patients who overused multiple drug classes reported more frequent use of acute medications (median [25th\u201375th percentiles]: 25.0 [15.0\u201330.0] vs. 17.5 [10.0\u201325.5] days\/month,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.029) and fewer crystal\u2010clear days (0.0 [0.0\u20139.5] vs. 9.0 [0.0\u201310.0] days\/month,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.048) than those who overused triptans. Patients who overused multiple drug classes also reported shorter intervals from chronic daily headache to the onset of MOH than patients who overused combination\u2010analgesics (0.6 [0.2\u20131.9] vs. 2.4 [0.7\u20135.4] years,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) or non\u2010opioid analgesics (1.5 [0.6\u20134.3] years,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004). Patients who overused multiple drug classes reported more emergency room visits (1.0 [0.0\u20131.0] visits\/year) than those who overused combination\u2010analgesics (0.0 [0.0\u20131.0],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.024) or non\u2010opioid analgesics (0.0 [0.0\u20131.0],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030). Patients who overused triptans reported fewer headache days (21.0 [20.0\u201330.0] vs. 30.0 [20.5\u201330.0] days\/month,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008) and fewer severe headache days (7.0 [4.0\u201310.0] vs. 10.0 [5.0\u201315.0] days\/month,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017) than those who overused non\u2010opioid analgesics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Some clinical characteristics of MOH significantly differed according to the class of overused medications. The findings from this study may contribute to the understanding of the clinical characteristics and pathophysiology of MOH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14363","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T06:13:15Z","timestamp":1657779195000},"page":"890-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical characteristics of medication\u2010overuse headache according to the class of acute medication: A cross\u2010sectional multicenter study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-1680","authenticated-orcid":false,"given":"Sun\u2010Young","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Neurology Jeonbuk National University Hospital &amp; School of Medicine  Jeonju South Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University\u2010Biomedical Research Institute of Jeonbuk National University Hospital  Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ju","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology Jeonbuk National University Hospital &amp; School of Medicine  Jeonju South Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University\u2010Biomedical Research Institute of Jeonbuk National University Hospital  Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8120-2469","authenticated-orcid":false,"given":"Hong\u2010Kyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inje University Ilsan Paik Hospital Inje University College of Medicine  Goyang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4053-3763","authenticated-orcid":false,"given":"Soo\u2010Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dongtan Sacred Heart Hospital Hallym University College of Medicine  South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-2831","authenticated-orcid":false,"given":"Yuha","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dongtan Sacred Heart Hospital Hallym University College of Medicine  South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heui\u2010Soo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-1969","authenticated-orcid":false,"given":"Mi Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Hospital, Ewha Womans University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Jin","family":"Im","sequence":"additional","affiliation":[{"name":"Center for Clinical Pharmacology and Biomedical Research Institute Jeonbuk National University Hospital  Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Jeong","family":"Son","sequence":"additional","affiliation":[{"name":"Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Ho","family":"Roh","sequence":"additional","affiliation":[{"name":"Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-1346","authenticated-orcid":false,"given":"Min Kyung","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00824-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.07.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413512033"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1987.0701015.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000120545.45443.93"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2021.17.4.546"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411398400"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0544-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30299-5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2021.17.1.77"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0580-y"},{"key":"e_1_2_11_14_1","article-title":"The epidemiology of primary headache disorders in Zambia: a population\u2010based door\u2010to\u2010door survey","volume":"16","author":"Mbewe E","year":"2015","journal-title":"J Headache Pain"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0759-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0669-y"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0704-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335946.53860.1d"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13674"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1646946"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.7.1011"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01365.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026119331193"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.suppl_1.S20"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_11_27_1","first-page":"1","article-title":"Validity and reliability assessment of Korean Headache Impact Test\u20106 (HIT\u20106)","volume":"27","author":"Chu MK","year":"2009","journal-title":"J Korean Neurol Assoc"},{"key":"e_1_2_11_28_1","first-page":"287","article-title":"The reliability and validity of the MIDAS (migraine disability assessment) questionnaire for Korean migraine sufferers","volume":"18","author":"Lee HS","year":"2000","journal-title":"J Korean Neurol Assoc"},{"key":"e_1_2_11_29_1","first-page":"114","article-title":"Standardization of the Korean version of patient health Questionnaire\u20109 as a screening instrument for major depressive disorder","volume":"28","author":"Choi HS","year":"2007","journal-title":"J Korean Acad Fam Med"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0583-8"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024211057184"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.2307\/1164717"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12550"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413515338"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024211006903"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-011-0234-y"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13641"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0081-y"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102409355600"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01183.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-126"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02151.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01914.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00647.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00683.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1996.1606419.x"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-009-0048-3"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01217.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10786"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.04.064"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000279519.99344.ad"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.09.004"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.05.34"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/00131640021970871"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/ortho\/24.2.139"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577511"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.14363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:39:49Z","timestamp":1762076389000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/head.14363"],"URL":"https:\/\/doi.org\/10.1111\/head.14363","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2021-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}