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POTS is a debilitating illness with few effective treatments. We aim for this narrative review to increase awareness of the mechanistic connections between POTS and migraine providing foundational information that optimizes clinical care and advances the development of pathophysiologic\u2010based treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the PubMed and Medline databases in November 2021 to perform a literature review and searched for the following keywords: \u201cpostural orthostatic tachycardia syndrome,\u201d \u201cPOTS,\u201d \u201cautonomic nervous system,\u201d AND \u201cmigraine,\u201d \u201cheadache.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The high prevalence of migraine in patients with POTS may be explained by common pathologic mechanisms. There is evidence that dysregulation of the sympathetic nervous system,\u00a0alterations in central and peripheral hemodynamics, and central sensitization increase vulnerability to both POTS and migraine. Non\u2010pharmacologic and pharmacologic treatments that target these shared mechanisms may provide significant benefit for the patient with POTS and migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Identification of common affected pathways may provide important insight that advances our understanding and treatment of both migraine and POTS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14365","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T07:05:15Z","timestamp":1658214315000},"page":"792-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Postural orthostatic tachycardia syndrome and migraine: A\u00a0narrative 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