{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:44:46Z","timestamp":1789044286053,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009329","name":"Foundation for Rehabilitation Psychology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Stigma is increasingly recognized as an important social feature of living with migraine.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Adults with migraine recruited from neurology offices completed the validated Stigma Scale for Chronic Illnesses 8\u2010item version (SSCI\u20108); two outcome measures (the Migraine Disability Assessment [MIDAS] and the Migraine\u2010Specific Quality of Life Questionnaire v 2.1 [MSQ]); and measures of allodynia (Allodynia Symptom Checklist [ASC\u201012]), pain cognition (Pain Catastrophizing Scale [PCS]), and psychiatric symptoms (Patient Reported Measurement Information System Anxiety [PROMIS\u2010A] and Depression [PROMIS\u2010D]). Pearson and Spearman correlations evaluated bivariate relationships, and linear (MSQ) and logistic (MIDAS Severe Disability, scores \u226521) regressions evaluated the unique variance associated with SSCI\u20108 beyond other study variables. Conditional process analysis evaluated mediation hypotheses between study variables.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants (\n n<\/jats:italic>\n \u00a0=\u00a0121) reported levels of stigma on par with other chronic illnesses (SSCI\u20108\u00a0\n M<\/jats:italic>\n \u00a0=\u00a053.0, standard deviation [SD]\u00a0=\u00a07.8), with 25\/127 (19.6%) reporting clinically significant levels of stigma (SSCI\u20108\u00a0\n T<\/jats:italic>\n \u2010score\u2009\u2265\u200960). Higher SSCI\u20108 scores were associated with higher monthly headache day frequency (\n r<\/jats:italic>\n \u00a0=\u00a00.35), MIDAS (\n \u03c1<\/jats:italic>\n \u00a0=\u00a00.41), ASC\u201012 (\n r<\/jats:italic>\n \u00a0=\u00a00.24,\n p<\/jats:italic>\n \u2009<\u20090.01), PCS (\n r<\/jats:italic>\n \u00a0=\u00a00.46), both PROMIS\u2010A (\n r<\/jats:italic>\n \u00a0=\u00a00.43) and D (\n r<\/jats:italic>\n \u00a0=\u00a00.42), and lower MSQ subscale scores (Role Restriction\n r<\/jats:italic>\n \u00a0=\u00a0\u22120.50; Role Prevention\n r<\/jats:italic>\n \u00a0=\u00a0\u22120.48; Emotion Function\n r<\/jats:italic>\n \u00a0=\u00a0\u22120.50), all\n p<\/jats:italic>\n s\u2009<0.001 unless otherwise noted. The SSCI\u20108 contributed significantly beyond migraine symptoms and other psychological factors for MSQ Emotion Function (5% unique variance) and MIDAS Severe Disability (6% of unique variance). The SSCI\u20108 mediated relationships between headache frequency and the MSQ subscales and MIDAS Severe Disability. The PCS mediated relationships between the SSCI\u20108 and MSQ subscales. The PROMIS\u2010D mediated relationships between the SSCI\u20108 and MSQ Role Restriction and MSQ Role Prevention.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Migraine stigma has medium to large associations with migraine outcomes and psychiatric symptoms and is independently associated with migraine disability and emotion\u2010related quality of life. Migraine stigma is an important contributor to the relationship between headache frequency and migraine outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.14401","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T10:35:40Z","timestamp":1667385340000},"page":"1354-1364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["The unique role of stigma in migraine\u2010related disability and quality of life"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8938-4949","authenticated-orcid":false,"given":"Elizabeth K.","family":"Seng","sequence":"first","affiliation":[{"name":"Ferkauf Graduate School of Psychology Yeshiva University Bronx New York USA"},{"name":"Saul R. Korey Department of Neurology Albert Einstein College of Medicine Bronx New York USA"},{"name":"Montefiore Headache Center Montefiore Medical Center Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Larner College of Medicine University of Vermont Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn C.","family":"Buse","sequence":"additional","affiliation":[{"name":"Ferkauf Graduate School of Psychology Yeshiva University Bronx New York USA"},{"name":"Saul R. Korey Department of Neurology Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-5333","authenticated-orcid":false,"given":"Matthew S.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Saul R. Korey Department of Neurology Albert Einstein College of Medicine Bronx New York USA"},{"name":"Montefiore Headache Center Montefiore Medical Center Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Parker","sequence":"additional","affiliation":[{"name":"VA New York Harbor Healthcare System New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21211"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-10019-10993-10190"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13914"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2012.08.2212"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13613"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.02.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.4159\/9780674028845","volume-title":"The Ecology of Human Development: Experiments by Nature and Design","author":"Brofenbrenner U","year":"1979"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327019eb0904_5"},{"issue":"38","key":"e_1_2_10_11_1","first-page":"269","article-title":"Felt versus enacted stigma: a concept revisited. 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