{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:16:30Z","timestamp":1762272990522,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the burden and consequences of migraine in Brazil in terms of health\u2010related quality of life (HRQoL), work productivity and daily activities, and healthcare resource utilization (HRU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite existing data on how migraine affects populations worldwide, there are limited data on the burden of migraine in Latin America.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study used patient\u2010reported data from the 2018 Brazil National Health and Wellness Survey. HRQoL scores (EuroQol 5\u2010dimension 5\u2010level [EQ\u20105D\u20105L]; 36\u2010item Short Form Health Survey, version 2 [SF\u201036v2]; and Short Form 6\u2010dimension [SF\u20106D]), impairments to work productivity and daily activities (Work Productivity and Activity Impairment questionnaire), and all\u2010cause HRU were compared between migraine respondents and matched non\u2010migraine controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 12,000 total respondents in the survey database, 1643 self\u2010reported a physician diagnosis of migraine and were propensity score matched 1:1 with controls without migraine. HRQoL was lower in patients with migraine versus non\u2010migraine controls, with significantly lower SF\u201036v2 physical (mean\u00a0[\u00b1\u2009SD] 50.3\u00a0[7.5] vs. 52.0\u00a0[7.6]) and mental component (mean [\u00b1\u2009SD] 42.9\u00a0[10.2] vs. 46.0\u00a0[9.9]) summary scores and SF\u20106D (mean [\u00b1\u2009SD] 0.7\u00a0[0.1] vs. 0.7\u00a0[0.1]) and EQ\u20105D\u20105L (mean [\u00b1\u2009SD] 0.7\u00a0[0.2] vs. 0.8\u00a0[0.2]) utility scores (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients with migraine reported higher levels of work productivity loss (mean\u00a0[\u00b1\u2009SD], 40.6%\u00a0[31.4%] vs. 28.6%\u00a0[30.9%], including absenteeism 12.8%\u00a0[19.1%] vs. 8.4%\u00a0[17.1%] and presenteeism 35.0%\u00a0[28.7%] vs. 24.8%\u00a0[28.0%]; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); activity impairment (mean\u00a0[\u00b1\u2009SD] 36.0%\u00a0[28.8%] vs. 25.5%\u00a0[28.1%];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); and significantly higher HRU in the past 6\u2009months (healthcare provider and emergency department visits [mean [\u00b1\u2009SD] 7.2\u00a0[9.5] vs. 4.5\u00a0[6.3] and 1.7\u00a0[3.8] vs. 0.9\u00a0[2.2]; both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001] and hospitalizations [mean [\u00b1\u2009SD] 0.4\u00a0[2.7] vs. 0.2\u00a0[1.1];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002]) than controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Migraine is associated with poorer HRQoL, higher all\u2010cause HRU, and greater activity impairment and work productivity loss versus non\u2010migraine controls in Brazil.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14413","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T06:11:23Z","timestamp":1669356683000},"page":"1302-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Burden of migraine in Brazil: A cross\u2010sectional real\u2010world study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4841-4491","authenticated-orcid":false,"given":"Marcio Nattan Portes","family":"Souza","sequence":"first","affiliation":[{"name":"Hospital das Cl\u00ednicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Teva Pharmaceutical Industries, Ltd.  West Chester Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Piha","sequence":"additional","affiliation":[{"name":"Teva Pharmaceutical Industries  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinat","family":"Ribalov","sequence":"additional","affiliation":[{"name":"Teva Pharmaceutical Industries Ltd.  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Lengil","sequence":"additional","affiliation":[{"name":"Teva Pharmaceutical Industries Ltd.  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa","family":"van der Laan","sequence":"additional","affiliation":[{"name":"Teva Pharmaceutical Industries  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Calderaro","sequence":"additional","affiliation":[{"name":"Hospital Samaritano Higien\u00f3polis  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Kantar Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12511"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12960-021-00580-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12513"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0946-z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0907-6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1039-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20150072"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2013000300008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1518-8787.2017051000090"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2018.1445267"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20186069"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-018-0322-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.12.018"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"volume-title":"SF\u201036 Health Survey: Manual and Interpretation Guide","year":"2000","author":"Ware JE","key":"e_1_2_11_17_1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-7713-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.09.006"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199304050-00006"},{"volume-title":"Proceedings of the 26th Annual SAS Users' Group International Conference","author":"Parsons LS","key":"e_1_2_11_21_1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-78"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.23.100901.140546"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.5.629"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00546.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-31"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2018.09.2098"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419889357"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2019.04.1308"},{"issue":"1","key":"e_1_2_11_30_1","first-page":"116","article-title":"IHC\u2010PO\u2010070 recurrent visits to the emergency department (ED) due to headache: economic burden and epidemiological profile [IHC abstract IHC\u2010PO\u2010070]","volume":"39","author":"Souza MCP","year":"2019","journal-title":"Cephalalgia"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X2015021"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.02.027"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2002000100030"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00757.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"volume-title":"Pesquisa Nacional por Amostra de Domic\u00edlios Cont\u00ednua\u2014PNAD Cont\u00ednua","author":"Instituto Brasileiro de Geografia e Estatistica","key":"e_1_2_11_36_1"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01782.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14218"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2016.1255750"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.03.037"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S132079"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.14413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:08:08Z","timestamp":1762078088000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/head.14413"],"URL":"https:\/\/doi.org\/10.1111\/head.14413","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"type":"print","value":"0017-8748"},{"type":"electronic","value":"1526-4610"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}