{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:04:02Z","timestamp":1780491842018,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effectiveness of onabotulinumtoxinA (BTX\u2010A) has been established in primary trigeminal neuralgia (TN). However, to the best of our knowledge, the efficacy of BTX\u2010A in secondary TN has not yet been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the efficacy of BTX\u2010A treatment in patients with multiple sclerosis\u2013related trigeminal neuralgia (TN\u2010MS) and compare the efficacy of BTX\u2010A treatment between patients with primary trigeminal neuralgia (TN\u2010P) and patients with TN\u2010MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective medical record\u2013review study. Demographic and clinical features and severity and frequency of pain before and 2\u2009weeks after the BTX\u2010A administration were extracted from the patient files. BTX\u2010A was injected into the painful area subcutaneously and\/or submucosally. BTX\u2010A injections were performed by the same physician using the same methods. A reduction in severity and\/or frequency of pain \u226550% was considered therapeutic efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010three patients were included in this study. We classified 22 (42%) as TN\u2010P and 31 (58%) as TN\u2010MS. Treatment with BTX\u2010A was effective in 16 of 31 (52%) patients with TN\u2010MS and 10 of 22 (45%) with TN\u2010P. BTX\u2010A treatment was less effective in patients with a history of interventional treatments and more effective in patients with concomitant continuous pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007; odds ratio [OR]: 0.020\u20130.53 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.047; OR: 0.046\u20130.98, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The BTX\u2010A treatment was found to be effective in at least half of our cohort with TN\u2010MS. Concomitant continuous pain and history of interventional treatments to the trigeminal nerve or ganglion might be predictive factors for the efficacy of BTX\u2010A treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14414","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T02:02:38Z","timestamp":1669600958000},"page":"1322-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of multiple sclerosis\u2013related trigeminal neuralgia with onabotulinumtoxinA"],"prefix":"10.1111","volume":"62","author":[{"given":"Furkan","family":"Asan","sequence":"first","affiliation":[{"name":"Department of Neurology, Cerrahpa\u015fa School of Medicine Istanbul University\u2013Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015feg\u00fcl","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerrahpa\u015fa School of Medicine Istanbul University\u2013Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melih","family":"T\u00fct\u00fcnc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerrahpa\u015fa School of Medicine Istanbul University\u2013Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"Uyguno\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerrahpa\u015fa School of Medicine Istanbul University\u2013Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feray Karaali","family":"Savrun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerrahpa\u015fa School of Medicine Istanbul University\u2013Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabahattin","family":"Saip","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerrahpa\u015fa School of Medicine Istanbul University\u2013Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aksel","family":"Siva","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerrahpa\u015fa School of Medicine Istanbul University\u2013Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-34"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416687280"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-65"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412441721"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-92"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13950"},{"issue":"2","key":"e_1_2_10_9_1","first-page":"396","article-title":"Trigeminal neuralgia","volume":"23","author":"Cruccu G","year":"2017","journal-title":"Contin Minneap 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