{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:43:03Z","timestamp":1792618983528,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess whether alcohol intake is associated with the onset of migraine attacks up to 2\u2009days after consumption in individuals with episodic migraine (EM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although alcohol has long been suspected to be a common migraine trigger, studies have been inconclusive in proving this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an observational prospective cohort study among individuals with migraine who registered to use a digital health platform for headache. Eligible individuals were aged \u226518\u2009years with EM who consumed alcohol and had tracked their headache symptoms and alcohol intake for \u226590\u2009days. People who did not drink any alcohol were excluded. The association of alcohol intake (\u201cYes\/No\u201d) and of the number of alcoholic beverages in the 2\u2009days preceding a migraine attack was assessed accounting for the presence of migraine on day\u20102 and its interaction with alcohol intake on day\u20102, and further adjusted for sex, age, and average weekly alcohol intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data on 487 individuals reporting 5913 migraine attacks and a total of 40,165 diary days were included in the analysis. Presence of migraine on day\u20102 and its interaction with alcohol intake on day\u20102 were not significant and removed from the model. At the population level, alcohol intake on day\u20102 was associated with a lower probability of migraine attack (OR [95% CI]\u00a0=\u00a00.75 [0.68, 0.82]; event rate 1006\/4679, 21.5%), while the effect of alcohol intake on day\u20101 was not significant (OR [95% CI]\u00a0=\u00a01.01 [0.91, 1.11]; event rate 1163\/4679, 24.9%) after adjusting for sex, age, and average weekly alcohol intake. Similar results were obtained with the number of beverages as exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this English\u2010speaking cohort of individuals with EM who identified themselves as mostly low\u2010dose alcohol consumers, there was no significant effect on the probability of a migraine attack in the 24\u2009h following consumption, and a slightly lower likelihood of a migraine attack from 24 to 48\u2009h following use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14428","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T02:02:25Z","timestamp":1669600945000},"page":"1329-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Alcohol as a trigger of migraine attacks in people with migraine. Results from a large prospective cohort study in English\u2010speaking countries"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8304-257X","authenticated-orcid":false,"given":"Marina","family":"Vives\u2010Mestres","sequence":"first","affiliation":[{"name":"Clinical Statistics Curelator Inc.  Massachusetts Cambridge USA"},{"name":"Department of Computer Science, Applied Mathematics and Statistics Universitat de Girona  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2507-0286","authenticated-orcid":false,"given":"Amparo","family":"Casanova","sequence":"additional","affiliation":[{"name":"Clinical Statistics Curelator Inc.  Massachusetts Cambridge USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6525-0498","authenticated-orcid":false,"given":"Xavier","family":"Puig","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operations Research Universitat Polit\u00e8cnica de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9521-9635","authenticated-orcid":false,"given":"Josep","family":"Ginebra","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operations Research Universitat Polit\u00e8cnica de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Neurology Zucker School of Medicine at Northwell Health  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407921102"},{"key":"e_1_2_11_3_1","volume-title":"Illustrated Susruta Samhita","author":"Murthy Srikantha KR","year":"2007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420919098"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010607"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-008-0006-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01279.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.10.119"},{"key":"e_1_2_11_10_1","first-page":"1","article-title":"An observational study of self\u2010reported migraine triggers and prospective evaluation of the relationships with occurrence of attacks enabled by a smartphone application (App)","author":"Casanova A","year":"2022","journal-title":"Headache"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01303.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00441.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-012-1046-5"},{"issue":"2","key":"e_1_2_11_14_1","first-page":"147","article-title":"Wine and migraine: compatibility or incompatibility?","volume":"25","author":"Nicolodi N","year":"1999","journal-title":"Drugs Exp Clin Res"},{"issue":"3","key":"e_1_2_11_15_1","first-page":"216","article-title":"Chocolate and migraine: the history of an ambiguous association","volume":"85","author":"Lippi G","year":"2014","journal-title":"Acta Biomed"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1708855.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711053171903"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1989.hed2902090.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1997.3703153.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.2.280"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2008.03.013"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105100"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416649761"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12464"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13422"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13943"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14199"},{"key":"e_1_2_11_28_1","unstructured":"N1\u2010Headache.Privacy Policy.https:\/\/n1\u2010headache.com\/privacy\u2010policy\/"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13507"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00235-4"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177011136"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14182"},{"key":"e_1_2_11_33_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"issue":"125","key":"e_1_2_11_34_1","first-page":"1","article-title":"JAGS: a program for analysis of Bayesian graphical models using Gibbs sampling","volume":"124","author":"Plummer M","year":"2003","journal-title":"Proceedings of the 3rd International Workshop on Distributed Statistical Computing"},{"key":"e_1_2_11_35_1","unstructured":"SuY\u2010S YajimaM.R2jags: Using R to run \u201cJAGS\u201d. 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