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Two reviewers independently selected studies, appraised methodological quality, and undertook a framework synthesis. We developed summary of findings tables following the approach of Grading of Recommendations, Assessment, Development and Evaluations Confidence in the Evidence from Reviews of Qualitative Research to assess confidence in the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1691 candidate references, we included 19 studies (21 publications) involving 459 patients. The studies mostly recruited White women from North America (11 studies) and Europe (8 studies). We identified eight themes encompassing features preferred by patients in a migraine treatment process. Themes described a treatment process that included shared decision\u2010making, a tailored approach, trust in health\u2010care professionals, sharing of knowledge and diversity of treatment options, a holistic approach that does not just address the headache, ease of communication especially for complex treatments, a non\u2010undermining approach, and reciprocity with mutual respect between patient and provider. In terms of the treatment itself, seven themes emerged including patients\u2019 preferences for nonpharmacologic treatment, high effectiveness, rapidity of action, long\u2010lasting effect, lower cost and more accessibility, self\u2010management\/self\u2010delivery option that increases autonomy, and a mixed preference for abortive versus prophylactic treatments. The treatment outcomes that have high value to patients included maintaining or improving function; avoiding side effects, potential for addiction to medications, and pain reoccurrence; and avoiding non\u2010headache symptoms such as nausea, vomiting, and sensitivity to light or sounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patient values and preferences were individually constructed, varied widely, and could be at odds with conventional medical perspectives and evidence of treatment effects. Considering the availability of numerous treatments for acute migraine, it is necessary that decision\u2010making incorporates patient values and preferences identified in qualitative research. The findings of this qualitative synthesis can be used to facilitate an individually tailored approach, strengthen the patient\u2013health\u2010care system relationship, and guide choices and decisions in the context of a clinical encounter or a clinical practice guideline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14430","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T07:40:37Z","timestamp":1672904437000},"page":"185-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A qualitative evidence synthesis of patient perspectives on migraine treatment features and outcomes"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-0922","authenticated-orcid":false,"given":"Meritxell","family":"Urtecho","sequence":"first","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Center  Rochester Minnesota USA"},{"name":"Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittin","family":"Wagner","sequence":"additional","affiliation":[{"name":"Minnesota Evidence\u2010Based Practice Center University of Minnesota School of Public Health  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Center  Rochester Minnesota USA"},{"name":"Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Health Care Delivery Research Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana H.","family":"VanderPluym","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Center  Rochester Minnesota USA"},{"name":"Department of Neurology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi B.","family":"Halker\u00a0Singh","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Center  Rochester Minnesota USA"},{"name":"Department of Neurology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Noyes","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Bangor University  Bangor UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Butler","sequence":"additional","affiliation":[{"name":"Minnesota Evidence\u2010Based Practice Center University of Minnesota School of Public Health  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hassan","family":"Murad","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Center  Rochester Minnesota USA"},{"name":"Robert D. and Patricia E. 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